ALK1 signaling regulates early postnatal lymphatic vessel development
about
Development of the mammalian lymphatic vasculatureLymphangiogenesis is required for pancreatic islet inflammation and diabetesALK1 signaling inhibits angiogenesis by cooperating with the Notch pathway.Activin receptor inhibitors--dalantercept.ALK1 as an emerging target for antiangiogenic therapy of cancerEndothelial depletion of Acvrl1 in mice leads to arteriovenous malformations associated with reduced endoglin expression.Tumor lymphangiogenesis as a potential therapeutic target.BMP9 and BMP10 are critical for postnatal retinal vascular remodeling.Molecular regulation of lymphangiogenesis in development and tumor microenvironment.Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development.Bone morphogenetic protein 9 (BMP9) controls lymphatic vessel maturation and valve formationTGFβ signaling is required for sprouting lymphangiogenesis during lymphatic network development in the skin.Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression.BMP-9 balances endothelial cell fate.Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma.Angiogenesis regulation by TGFβ signalling: clues from an inherited vascular disease.Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.Lymphangiogenic factors, mechanisms, and applications.Essential role for TMEM100 in vascular integrity but limited contributions to the pathogenesis of hereditary haemorrhagic telangiectasia.ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapiesAnti-human activin receptor-like kinase 1 (ALK1) antibody attenuates bone morphogenetic protein 9 (BMP9)-induced ALK1 signaling and interferes with endothelial cell sprouting.BMP9 is produced by hepatocytes and circulates mainly in an active mature form complexed to its prodomain.Epigenetics and cell death: DNA hypermethylation in programmed retinal cell death.Physiology. Lymphatics are in my veins.Tacrolimus rescues the signaling and gene expression signature of endothelial ALK1 loss-of-function and improves HHT vascular pathology.Reduced activin receptor-like kinase 1 activity promotes cardiac fibrosis in heart failure.A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.Bone Morphogenetic Proteins.ALK1 expression in oral lichen planus: a possible relation to microvessel density.
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ALK1 signaling regulates early postnatal lymphatic vessel development
description
2010 nî lūn-bûn
@nan
2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
ALK1 signaling regulates early postnatal lymphatic vessel development
@ast
ALK1 signaling regulates early postnatal lymphatic vessel development
@en
ALK1 signaling regulates early postnatal lymphatic vessel development
@en-gb
ALK1 signaling regulates early postnatal lymphatic vessel development
@nl
type
label
ALK1 signaling regulates early postnatal lymphatic vessel development
@ast
ALK1 signaling regulates early postnatal lymphatic vessel development
@en
ALK1 signaling regulates early postnatal lymphatic vessel development
@en-gb
ALK1 signaling regulates early postnatal lymphatic vessel development
@nl
prefLabel
ALK1 signaling regulates early postnatal lymphatic vessel development
@ast
ALK1 signaling regulates early postnatal lymphatic vessel development
@en
ALK1 signaling regulates early postnatal lymphatic vessel development
@en-gb
ALK1 signaling regulates early postnatal lymphatic vessel development
@nl
P2093
P2860
P921
P3181
P1433
P1476
ALK1 signaling regulates early postnatal lymphatic vessel development
@en
P2093
John Brady Ridgway
Kyle Niessen
Minhong Yan
P2860
P304
P3181
P356
10.1182/BLOOD-2009-07-235655
P407
P577
2010-02-25T00:00:00Z