Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
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NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradationDcas supports cell polarization and cell-cell adhesion complexes in developmentDirect interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cellsMICAL, a novel CasL interacting molecule, associates with vimentinP130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreadingCell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligandThe centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1The docking protein HEF1 is an apoptotic mediator at focal adhesion sitesA novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1CAS proteins in normal and pathological cell growth controlThe adaptor protein Crk in immune responsePreclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseasesCytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinaseProteolysis of the docking protein HEF1 and implications for focal adhesion dynamicsRegulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesionMolecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycleRegulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathwaysBCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with CrklT cell receptor-mediated tyrosine phosphorylation of Cas-L, a 105-kDa Crk-associated substrate-related protein, and its association of Crk and C3GAssociation of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cellsA requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 micePSTPIP 2, a second tyrosine phosphorylated, cytoskeletal-associated protein that binds a PEST-type protein-tyrosine phosphataseRegulation of fibroblast motility by the protein tyrosine phosphatase PTP-PESTPTP-PEST, a scaffold protein tyrosine phosphatase, negatively regulates lymphocyte activation by targeting a unique set of substratesRegulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation.Role of the β1 integrin molecule in T-cell activation and migration.The adapter protein Crkl links Cbl to C3G after integrin ligation and enhances cell migration.Involvement of the adapter protein CRKL in integrin-mediated adhesion.Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf.Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamicsRoles of protein tyrosine phosphatases in cell migration and adhesion.Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways.An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cellsBioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer
P2860
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P2860
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
description
1997 nî lūn-bûn
@nan
1997 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@ast
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en-gb
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@nl
type
label
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@ast
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en-gb
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@nl
prefLabel
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@ast
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en-gb
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@nl
P2093
P50
P921
P356
P1476
Involvement of p130(Cas) and p ...... igen receptor on human B cells
@en
P2093
A S Freedman
E A Golemis
J D Griffin
N Haghayeghi
P304
P356
10.1074/JBC.272.7.4230
P407
P577
1997-02-01T00:00:00Z