Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
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NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migrationA novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levelsHuman enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosisCAS proteins in normal and pathological cell growth controlAND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphologyNEDD9 promotes oncogenic signaling in mammary tumor development.Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseasesMolecular basis for HEF1/NEDD9/Cas-L action as a multifunctional co-ordinator of invasion, apoptosis and cell cycleOverexpression of Nedd9 is a prognostic marker of human gastric cancerNedd9 restrains renal cystogenesis in Pkd1-/- miceA novel Cas family member, HEPL, regulates FAK and cell spreading.The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosomeA requirement for Nedd9 in luminal progenitor cells prior to mammary tumorigenesis in MMTV-HER2/ErbB2 miceHEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networksNEDD9 promotes lung cancer metastasis through epithelial-mesenchymal transitionSynergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3.Caspase-3 regulates catalytic activity and scaffolding functions of the protein tyrosine phosphatase PEST, a novel modulator of the apoptotic response.The WW-HECT protein Smurf2 interacts with the Docking Protein NEDD9/HEF1 for Aurora A activation.Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions.Synthetic lethal screen of an EGFR-centered network to improve targeted therapies.The N-end rule pathway and regulation by proteolysisRapid calcium-dependent activation of Aurora-A kinase.Enhanced genetic instability and dasatinib sensitivity in mammary tumor cells lacking NEDD9The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle.Integrins in invasive growth.An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics.Aurora A kinase activity influences calcium signaling in kidney cells.Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell deathThe expressions of NEDD9 and E-cadherin correlate with metastasis and poor prognosis in triple-negative breast cancer patients.Pathway-specific profiling identifies the NF-kappa B-dependent tumor necrosis factor alpha-regulated genes in epidermal keratinocytes.Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils.Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway.The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells.Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases.Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior.NEDD9 overexpression correlates with the progression and prognosis in gastric carcinoma.Integration of Canonical and Noncanonical Pathways in TLR4 Signaling: Complex Regulation of the Wound Repair Program.
P2860
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P2860
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@ast
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@en
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@nl
type
label
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@ast
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@en
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@nl
prefLabel
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@ast
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@en
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@nl
P2860
P3181
P1476
Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics
@en
P2093
E A Golemis
G M O'Neill
P2860
P304
P3181
P356
10.1128/MCB.21.15.5094-5108.2001
P407
P577
2001-08-01T00:00:00Z