Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2
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Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicityThe evolution of function within the Nudix homology clan.A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target.A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopeniaInherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.Validation and development of MTH1 inhibitors for treatment of cancer.Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesisAn increase of oxidised nucleotides activates DNA damage checkpoint pathway that regulates post-embryonic development in Caenorhabditis elegansBattle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells.Versatile physiological functions of the Nudix hydrolase family in Arabidopsis.Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease.Update on thiopurine pharmacogenetics in inflammatory bowel disease.Deoxyribonucleotide metabolism, mutagenesis and cancer.The druggability of intracellular nucleotide-degrading enzymes.Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis.Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases.NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.Search for proteins required for accurate gene expression under oxidative stress: roles of guanylate kinase and RNA polymerase.Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors.Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?Phosphate bond hydrolysis by NUDT proteinsMutT-related proteins are novel progression and prognostic markers for colorectal cancer.A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMPNUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMPNUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMPNUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMPNUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMPNUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMPNUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy.NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia.
P2860
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P248
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P2860
Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2
description
2012 nî lūn-bûn
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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@ast
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en-gb
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@nl
type
label
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@ast
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en-gb
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@nl
prefLabel
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@ast
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en-gb
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@nl
P2093
P2860
P921
P356
P1476
Human MTH3 (NUDT18) protein hy ...... comparison with MTH1 and MTH2
@en
P2093
Daiki Setoyama
Hiroyuki Kamiya
Mutsuo Sekiguchi
Riyoko Ito
Yasumitsu Takagi
Yuriko Yamagata
P2860
P304
P356
10.1074/JBC.M112.363010
P407
P577
2012-06-15T00:00:00Z