Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia. - Wikidata - awgldk - TriplyDB

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

http://www.wikidata.org/entity/Q34478851

about

Pharmacogenomics in Pediatric Oncology: Review of Gene-Drug Associations for Clinical Use NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment.Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose.Review article: recent advances in pharmacogenetics and pharmacokinetics for safe and effective thiopurine therapy in inflammatory bowel disease.The druggability of intracellular nucleotide-degrading enzymes.Pharmacogenomics in pediatric acute lymphoblastic leukemia: promises and limitations.Toward Optimum Benefit-Risk and Reduced Access Lag For Cancer Drugs in Asia: A Global Development Framework Guided by Clinical Pharmacology Principles.Combined Detection of NUDT15 Variants Could Highly Predict Thiopurine-induced Leukopenia in Chinese Patients with Inflammatory Bowel Disease: A Multicenter Analysis.Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia.Pharmacogenetic Predictors of Treatment-Related Toxicity Among Children With Acute Lymphoblastic Leukemia.Association of NUDT15 c.415C>T allele and thiopurine-induced leukocytopenia in Asians: a systematic review and meta-analysis.Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age.NUDT15, FTO, and RUNX1 genetic variants and thiopurine intolerance among Japanese patients with inflammatory bowel diseases.NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.Novel Tetra-Primer ARMS-PCR Assays for Thiopurine Intolerance Susceptibility Mutations NUDT15 c.415C>T and TPMT c.719A>G (TPMT*3C) in East Asians.Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping.APEX1 Polymorphism and Mercaptopurine-Related Early Onset Neutropenia in Pediatric Acute Lymphoblastic Leukemia.NUDT15 Variants Cause Hematopoietic Toxicity with Low 6-TGN Levels in Children with Acute Lymphoblastic Leukemia.The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia.Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon.Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report.Preclinical evaluation of NUDT15-guided thiopurine therapy and its effects on toxicity and anti-leukemic efficacy.Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia.NUDT15 R139C Variants Increase the Risk of Azathioprine-Induced Leukopenia in Chinese Autoimmune Patients.Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants?NUDT15 R139C variation increases the risk of azathioprine-induced toxicity in Chinese subjects: Case report and literature review.

P2860

Q28068930-58A39F44-B17A-473C-A306-4072B63CB298 Q28115755-5199A4F0-ADC9-40C9-9795-FD32843AE1AD Q30244222-19A5FB88-BC62-42CD-8965-E25622C55736 Q33632120-EEF0C685-CBA3-4E93-A657-92BB76D9C779 Q34549324-17906323-B650-4354-AE64-A3F154F1E51B Q38417177-87E904D4-955C-49DC-8E83-1ED5D2ADE42A Q38650970-827BF54F-F13A-47C5-9264-B93AA4C4BB0B Q38688039-084263FB-B0CC-41FF-93EC-9D2799B3937F Q38719689-29002450-36B4-4B30-BEF9-B310E7A89289 Q38750966-B11E1165-6CF1-486E-8426-AE345E9FD454 Q38832951-7CCA9DD9-4A1E-4EDD-AE54-DCF0D077DE39 Q38895172-B1E72D15-23D1-4FB3-A24F-5E303334B93B Q39282446-B78D879C-2933-49C7-9E47-40F35B1218F8 Q39756044-22C66D88-CC3A-48AA-98A0-DCEF06909158 Q41080533-95675101-3635-48C4-ADF3-BCB565CB040D Q43109007-FD12EAC3-3FBC-4E24-843F-FF704B3A437F Q47114058-AAF2207B-A07F-4D26-A7C9-F76E94BAF398 Q47344295-12A94670-EE74-480C-B0C0-6EE75B764BE4 Q48019540-F2B9D8FE-C0CB-458B-AA4D-692D290BEBE9 Q50115786-C86BA1A8-3ABF-4CBC-AD98-36223FB4C17F Q50209400-4ECD99A3-5F9A-4A1C-B532-2A5BAE99E29B Q50433542-FB190382-8443-47F1-B85E-F8BCF177EA74 Q51541761-256249F1-23E4-48F6-95CA-08E3E911E54C Q51641578-ED9B4D86-BA9E-45DF-B1EB-D7E5498D51C2 Q51661869-AAED96D0-FCF5-48C3-8FED-45C10A159223 Q51735726-EF40BAF7-6EE3-4F84-A6AB-CF7FA719D5B3 Q52665811-8D807A9D-A58D-4B14-B917-9C0668BFA61A Q54975027-B4C78430-7A27-481E-98DF-AC6C15798B24 Q55064299-10A30ACE-4062-4A2C-A5AF-753AC3DFF5AF Q55396788-58444C70-DC2E-45D0-A467-7181E5696EA3

P2860

Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

http://www.wikidata.org/entity/Q34478851

description

2015 nî lūn-bûn

@nan

2015 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@ast

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@en

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@nl

type

label

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@ast

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@en

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@nl

prefLabel

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@ast

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@en

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@nl

P1433

Q34478851-D120B18A-C79E-4C52-9F93-756E610AD5B9

P1476

Q34478851-A3667928-C5A7-42D7-A6C5-7B004C9358AC

P2093

Q34478851-02CA8493-3A22-4176-B9C3-D82EA1B70FD2

Q34478851-456C76D8-A137-46B8-8147-015C1D273D27

Q34478851-5656CA22-4DE6-4113-ADFF-0A5F225F3C07

Q34478851-7263BC23-D8D4-4AFF-9A89-78B7120EA71B

Q34478851-924A63BD-A09E-4DDD-9222-3375408BE3E8

Q34478851-A830D088-9F97-43D9-96E3-167D4DE9E1C6

Q34478851-D5FFE44F-9CFB-49D0-977B-6D3471A877CC

Q34478851-ED4718A4-7544-49BD-821C-7BA13322284B

P2860

Q34478851-30B9DB37-9FFA-4CC9-AE79-24126EFE3296

Q34478851-3AE39F9D-071E-4F0B-BE9B-18EB2B69F06C

Q34478851-4BF6AA94-4652-4313-898F-B4B475648140

Q34478851-4DF1975C-C8DC-42BC-B78C-0B88671646E4

Q34478851-93A3AB47-75A7-40E8-864F-09EB20C8666D

Q34478851-A98F01A4-110C-44D7-9EA5-022B63C2A8B1

Q34478851-AC42A67D-BEC3-4D37-A958-C988DAD49096

Q34478851-ACB18CA1-4852-4625-982C-E45C4DF284CA

Q34478851-D1FF0D5B-85AA-4B1E-BF08-AAA30F2FBE10

Q34478851-DC8BCABA-279A-48F4-AD9A-E9EEE4061B89

P304

Q34478851-773D3212-F204-45FE-B89D-789E0179482C

P31

Q34478851-3CC23010-AB35-4A68-83A5-E7D9DA4E616B

P356

Q34478851-673A656E-C2E5-412D-996A-868BD714D4D5

P407

Q34478851-AA6FDA89-1442-4500-B105-A1C2CFF5A60D

P433

Q34478851-2859E324-A770-4BD4-8868-F5E35D307D61

P478

Q34478851-C61BBA64-7009-4E96-A866-6CE927376451

P50

Q34478851-DF4640CA-A32D-4D22-B629-E45600BCE2B5

Q34478851-F2DABA1C-52B0-4A8C-B4B7-2152803F40B5

P577

Q34478851-B2C54670-6BF7-43C1-8F35-D79D15D35B80

P698

Q34478851-B143C5D2-6D0A-4A1F-A1F7-F1A547223B2C

P921

Q34478851-B44FF207-BC2A-4FE7-975D-EAC468BD0C73

P356

P1433

British Journal of Haematology

P1476

Susceptibility to 6-MP toxicit ...... acute lymphoblastic leukaemia.

@en

P2093

Atsushi Manabe

http://www.w3.org/2001/XMLSchema#string

Hisaya Nakadate

http://www.w3.org/2001/XMLSchema#string

Katsuyoshi Koh

http://www.w3.org/2001/XMLSchema#string

Kensuke Kondoh

http://www.w3.org/2001/XMLSchema#string

Kevin Y Urayama

http://www.w3.org/2001/XMLSchema#string

Kozue Nakamura

http://www.w3.org/2001/XMLSchema#string

Takako Komiyama

http://www.w3.org/2001/XMLSchema#string

Yoichi Tanaka

http://www.w3.org/2001/XMLSchema#string

P2860

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

Frequencies of thiopurine S-methyltransferase mutant alleles (TPMT*2, *3A, *3B and *3C) in 151 healthy Japanese subjects and the inheritance of TPMT*3C in the family of a propositus

Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

Pharmacogenomics of acute lymphoid leukemia: new insights into treatment toxicity and efficacy.

Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese.

Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia.

Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity.

P304

109-115

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1111/BJH.13518

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

171

http://www.w3.org/2001/XMLSchema#string

P50

Daisuke Hasegawa

P577

2015-06-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

26033531

http://www.w3.org/2001/XMLSchema#string

P921