Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
about
A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferationLhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye developmentEvidence of cancer-promoting roles for AMPK and related kinasesAMPKα1 deficiency promotes cellular proliferation and DNA damage via p21 reduction in mouse embryonic fibroblasts.Mitochondrial effectors of cellular senescence: beyond the free radical theory of agingMechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.Muscle-specific knock-out of NUAK family SNF1-like kinase 1 (NUAK1) prevents high fat diet-induced glucose intoleranceMapping cis- and trans-regulatory effects across multiple tissues in twins.Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging.Whole Chromosome Instability induces senescence and promotes SASP.The LKB1 tumor suppressor differentially affects anchorage independent growth of HPV positive cervical cancer cell linesMolecular mechanisms of tumor suppression by LKB1.Beyond ATM: the protein kinase landscape of the DNA damage response.The LKB1 complex-AMPK pathway: the tree that hides the forestCellular senescence: a double-edged sword in the fight against cancer.Polar opposites: Fine-tuning cytokinesis through SIN asymmetry.Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling.Overexpression of NUAK1 is associated with disease-free survival and overall survival in patients with gastric cancer.Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinasesLKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of YapBayesian Network Inference Modeling Identifies TRIB1 as a Novel Regulator of Cell-Cycle Progression and Survival in Cancer Cells.LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma.Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.The Janus face of p21.The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.Deregulated MYC expression induces dependence upon AMPK-related kinase 5.The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape.Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion.NUAK1 links genomic instability and senescence.Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence.Calcium signalling links MYC to NUAK1.The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway.Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.Maternal protein restriction affects gene expression profiles in the kidney at weaning with implications for the regulation of renal function and lifespan.A feed forward loop enforces YAP/TAZ signaling during tumorigenesis
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P2860
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@ast
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en-gb
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@nl
type
label
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@ast
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en-gb
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@nl
prefLabel
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@ast
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en-gb
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@nl
P2093
P2860
P3181
P356
P1433
P1476
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1
@en
P2093
Arnaud Augert
Corinne Abbadie
David Bernard
David Carling
Dolores Martinez
Marco Da Costa
Naveenan Navaratnam
Nicolas Humbert
P2860
P304
P3181
P356
10.1038/EMBOJ.2009.342
P407
P577
2010-01-20T00:00:00Z