Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
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Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infectionPhosphorylation of the autophagy receptor optineurin restricts Salmonella growthHaploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementiaPaget's disease of bone: an osteoimmunological disorder?Functional analysis of optineurin and some of its disease-associated mutantsAutophagy in the regulation of pathogen replication and adaptive immunityPosttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma geneLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsRegulation of autophagy by the Rab GTPase networkA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinThe TBK1-binding domain of optineurin promotes type I interferon responsesTBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome MaturationRegulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.Impairment of protein trafficking upon overexpression and mutation of optineurin.Serial analysis of gene expression (SAGE) in normal human trabecular meshwork.E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.12q14 Microdeletions: Additional Case Series with Confirmation of a Macrocephaly RegionDNA copy number variants of known glaucoma genes in relation to primary open-angle glaucomaCommon and rare genetic risk factors for glaucoma.Copy number variations on chromosome 12q14 in patients with normal tension glaucomaCopy number variations of TBK1 in Australian patients with primary open-angle glaucoma.TBK1 gene duplication and normal-tension glaucoma.The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling.Copy number variations and primary open-angle glaucoma.Optineurin regulates the interferon response in a cell cycle-dependent mannerExome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease.Confirmation of TBK1 duplication in normal tension glaucomaMutations in the ubiquitin-binding domain of OPTN/optineurin interfere with autophagy-mediated degradation of misfolded proteins by a dominant-negative mechanism.SQSTM1 Mutations and Glaucoma.The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote MitophagyIn Silico Knockout Studies of Xenophagic Capturing of Salmonella.Identification of an Alu-repeat-mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype.Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.Cellular and molecular biology of optineurin.Optineurin coding variants in Ghanaian patients with primary open-angle glaucomaComparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathwaysTBK1 and flanking genes in human retina.Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma.
P2860
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P2860
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
description
2008 nî lūn-bûn
@nan
2008 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մարտին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@ast
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en-gb
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@nl
type
label
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@ast
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en-gb
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@nl
prefLabel
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@ast
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en-gb
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@nl
P2093
P2860
P3181
P1433
P1476
Enhanced binding of TBK1 by an ...... of primary open angle glaucoma
@en
P2093
Luke Hesson
Mark Peggie
Philip Cohen
Simon Morton
P2860
P304
P3181
P356
10.1016/J.FEBSLET.2008.02.047
P407
P577
2008-03-19T00:00:00Z