NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
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Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathologyOptineurin negatively regulates the induction of IFNbeta in response to RNA virus infectionOverexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in miceFunctional analysis of optineurin and some of its disease-associated mutantsPosttranslational modifications, localization, and protein interactions of optineurin, the product of a glaucoma geneLoss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamicsMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinProcessing of optineurin in neuronal cellsEffects of optineurin siRNA on apoptotic genes and apoptosis in RGC-5 cellsM98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cellsRegulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant.Regulation of PSMB5 protein and β subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy.Impairment of protein trafficking upon overexpression and mutation of optineurin.Optineurin is required for CYLD-dependent inhibition of TNFα-induced NF-κB activation.Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.E3-14.7K is recruited to TNF-receptor 1 and blocks TNF cytolysis independent from interaction with optineurinE50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Focus on molecular events in the anterior chamber leading to glaucoma.Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Absence of altered expression of optineurin in primary open angle glaucoma patients.Optineurin Negatively Regulates Osteoclast Differentiation by Modulating NF-κB and Interferon Signaling: Implications for Paget's DiseaseIdentification of an Alu-repeat-mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype.Cellular and molecular biology of optineurin.Myocilin and Optineurin: Differential Characteristics and Functional ConsequencesEffects of mutations and deletions in the human optineurin gene.Complex genetic mechanisms in glaucoma: an overviewToward an integrative view of Optineurin functions.Unconventional MAPK-GSK-3β Pathway Behind Atypical Epithelial-Mesenchymal Transition In Hepatocellular CarcinomaThe Outflow Pathway: A Tissue With Morphological and Functional Unity.Optineurin associates with the podocyte Golgi complex to maintain its structure.Visual impairment in an optineurin mouse model of primary open-angle glaucoma.Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.Expression of optineurin isolated from rat-injured dental pulp and the effects on inflammatory signals in normal rat kidney cells.Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.X-linked inhibitor of apoptosis-associated factor 1 regulates TNF receptor 1 complex stability.Genetics of glaucoma.Autophagy and Ubiquitination in Salmonella Infection and the Related Inflammatory Responses.Optineurin Functions for Optimal Immunity.
P2860
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P2860
NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB.
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@ast
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@en
type
label
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@ast
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@en
prefLabel
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@ast
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@en
P2093
P2860
P1433
P1476
NF-kappaB mediates tumor necro ...... gative regulator of NF-kappaB.
@en
P2093
Ananthamurthy Nagabhushana
Cherukuri Sudhakar
Nishant Jain
P2860
P356
10.1371/JOURNAL.PONE.0005114
P407
P577
2009-04-02T00:00:00Z