LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
about
Targeting LKB1 in cancer - exposing and exploiting vulnerabilitiesReserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tractMultifocal epithelial tumors and field cancerization: stroma as a primary determinantThe LKB1-AMPK pathway: metabolism and growth control in tumour suppressionEndothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1.Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestineLKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiationAbsence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor functionChemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in miceLoss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathwaysPre-clinical study of drug combinations that reduce breast cancer burden due to aberrant mTOR and metabolism promoted by LKB1 loss.Resistance of R-Ras knockout mice to skin tumour inductionLkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways.mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome.LKB1; linking cell structure and tumor suppression.Dysregulation of mTOR activity through LKB1 inactivation.BRG1 and LKB1: tales of two tumor suppressor genes on chromosome 19p and lung cancer.The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.Peutz-Jeghers syndrome with small intestinal malignancy and cervical carcinomaTargeting the LKB1 tumor suppressor.LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.AMP-activated protein kinase α2 and E2F1 transcription factor mediate doxorubicin-induced cytotoxicity by forming a positive signal loop in mouse embryonic fibroblasts and non-carcinoma cells.Tumor stem cell, or its niche, which plays a primary role in tumorigenesis?Molecular mechanisms of tumor suppression by LKB1.LKB1 loss of function studied in vivo.The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling.LKB1 signaling in advancing cell differentiation.The tumor suppressor kinase LKB1: lessons from mouse models.The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis.Unravelling the connection between metabolism and tumorigenesis through studies of the liver kinase B1 tumour suppressor.Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues.The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signalingRunx3 in Immunity, Inflammation and Cancer.LKB1 as a Tumor Suppressor in Uterine Cancer: Mouse Models and Translational Studies.Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.Impaired gastric gland differentiation in Peutz-Jeghers syndrome.Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition.mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome
P2860
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P2860
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@ast
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en-gb
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@nl
type
label
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@ast
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en-gb
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@nl
prefLabel
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@ast
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en-gb
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@nl
P2093
P50
P3181
P356
P1433
P1476
LKB1 signaling in mesenchymal ...... of gastrointestinal polyposis
@en
P2093
Ari Ristimäki
Eeva Ventelä
Niklas Ekman
Ronald A DePinho
P2888
P3181
P356
10.1038/NG.98
P407
P577
2008-04-01T00:00:00Z
P5875
P6179
1000381092