Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting
about
SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactomeSCIMP, a transmembrane adaptor protein involved in major histocompatibility complex class II signalingHematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytesTumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.Characterization of phosphopeptide motifs specific for the Src homology 2 domains of signal transducer and activator of transcription 1 (STAT1) and STAT3.Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.Specificity and affinity motifs for Grb2 SH2-ligand interactionsImmunofluorescence assay and flow-cytometry selection of bead-bound aptamersGrb2 SH2 domain-binding peptide analogs as potential anticancer agents.Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries.On-bead screening of combinatorial libraries: reduction of nonspecific binding by decreasing surface ligand density.Instrumental biosensors: new perspectives for the analysis of biomolecular interactions.High-throughput screening of one-bead-one-compound libraries: identification of cyclic peptidyl inhibitors against calcineurin/NFAT interaction.Flow cytometry and cell sorting of heterogeneous microbial populations: the importance of single-cell analysesThe application of modular protein domains in proteomicsOn-bead screens sample narrower affinity ranges of protein-ligand interactions compared to equivalent solution assays.Identification of phosphopeptide ligands for the Src-homology 2 (SH2) domain of Grb2 by phage display.Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.Activation of target signal transducers utilizing chimeric receptors with signaling-molecule binding motifs.Fluorescence intensity multiple distributions analysis: concurrent determination of diffusion times and molecular brightness.
P2860
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P2860
Rapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sorting
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
name
Rapid identification of phosph ...... escence-activated bead sorting
@ast
Rapid identification of phosph ...... escence-activated bead sorting
@en
Rapid identification of phosph ...... escence-activated bead sorting
@en-gb
Rapid identification of phosph ...... escence-activated bead sorting
@nl
type
label
Rapid identification of phosph ...... escence-activated bead sorting
@ast
Rapid identification of phosph ...... escence-activated bead sorting
@en
Rapid identification of phosph ...... escence-activated bead sorting
@en-gb
Rapid identification of phosph ...... escence-activated bead sorting
@nl
prefLabel
Rapid identification of phosph ...... escence-activated bead sorting
@ast
Rapid identification of phosph ...... escence-activated bead sorting
@en
Rapid identification of phosph ...... escence-activated bead sorting
@en-gb
Rapid identification of phosph ...... escence-activated bead sorting
@nl
P2093
P2860
P356
P1476
Rapid identification of phosph ...... escence-activated bead sorting
@en
P2093
F Grossmüller
F O Gombert
P2860
P304
P356
10.1074/JBC.271.28.16500
P407
P577
1996-07-12T00:00:00Z