A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
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Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast cancer.SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activationFunctional association between SLAP-130 and SLP-76 in Jurkat T cellsA phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cellsClass II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptorsUse of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasisSubdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationAdaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cellsNuclear IGF1R is a transcriptional co-activator of LEF1/TCFHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorSos-mediated activation of rac1 by p66shcPhosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainNon-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptorThe phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptorActivation of Src family kinases by colony stimulating factor-1, and their association with its receptorDistinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domainsMolecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sitesThe role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signalingAssociation of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cellsIn vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinaseThe phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor proteinEphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxisRole of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesisA novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent mannerAn X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cellsDemonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitroRapid identification of phosphopeptide ligands for SH2 domains. Screening of peptide libraries by fluorescence-activated bead sortingBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayG protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexesThe SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signallingTyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulationEpidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsCytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalinThe coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferationThe neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathwaysThe heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytesSignal transduction by the high-affinity GM-CSF receptor: two distinct cytoplasmic regions of the common beta subunit responsible for different signalingEps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals
P2860
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P2860
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
description
1992 nî lūn-bûn
@nan
1992 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
A novel transforming protein ( ...... mitogenic signal transduction
@ast
A novel transforming protein ( ...... mitogenic signal transduction
@en
A novel transforming protein ( ...... mitogenic signal transduction
@en-gb
A novel transforming protein ( ...... mitogenic signal transduction
@nl
type
label
A novel transforming protein ( ...... mitogenic signal transduction
@ast
A novel transforming protein ( ...... mitogenic signal transduction
@en
A novel transforming protein ( ...... mitogenic signal transduction
@en-gb
A novel transforming protein ( ...... mitogenic signal transduction
@nl
prefLabel
A novel transforming protein ( ...... mitogenic signal transduction
@ast
A novel transforming protein ( ...... mitogenic signal transduction
@en
A novel transforming protein ( ...... mitogenic signal transduction
@en-gb
A novel transforming protein ( ...... mitogenic signal transduction
@nl
P2093
P3181
P1433
P1476
A novel transforming protein ( ...... mitogenic signal transduction
@en
P2093
F Grignani
I Nicoletti
L Lanfrancone
P G Pelicci
P304
P3181
P356
10.1016/0092-8674(92)90536-L
P407
P577
1992-07-10T00:00:00Z