about
A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagyA MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsThe amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neuronsConservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimerA unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8Selective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.E2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationA novel protein-conjugating system for Ufm1, a ubiquitin-fold modifierTRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexesAn intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalphaIdentification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexThe reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathwayConjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor functionThe Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimerThe Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and RepairInhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapyBuilding and remodelling Cullin-RING E3 ubiquitin ligasesGraded Proteasome Dysfunction in Caenorhabditis elegans Activates an Adaptive Response Involving the Conserved SKN-1 and ELT-2 Transcription Factors and the Autophagy-Lysosome PathwayInsights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinityStructural Dissection of a Gating Mechanism Preventing Misactivation of Ubiquitin by NEDD8’s E1 † ‡A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.The APC11 RING-H2 finger mediates E2-dependent ubiquitination.Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagyUbiquitylation, neddylation and the DNA damage responseCovalent modification of all members of human cullin family proteins by NEDD8Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitinationA dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivoMouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid methodPleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzymeThe NEDD8 system is essential for cell cycle progression and morphogenetic pathway in miceComponents of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycleCul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesisCUL-4A is critical for early embryonic developmentDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexCRL4A(CRBN) E3 ubiquitin ligase restricts BK channel activity and prevents epileptogenesis.
P2860
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P2860
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
A new NEDD8-ligating system for cullin-4A
@ast
A new NEDD8-ligating system for cullin-4A
@en
A new NEDD8-ligating system for cullin-4A
@en-gb
A new NEDD8-ligating system for cullin-4A
@nl
type
label
A new NEDD8-ligating system for cullin-4A
@ast
A new NEDD8-ligating system for cullin-4A
@en
A new NEDD8-ligating system for cullin-4A
@en-gb
A new NEDD8-ligating system for cullin-4A
@nl
prefLabel
A new NEDD8-ligating system for cullin-4A
@ast
A new NEDD8-ligating system for cullin-4A
@en
A new NEDD8-ligating system for cullin-4A
@en-gb
A new NEDD8-ligating system for cullin-4A
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
A new NEDD8-ligating system for cullin-4A
@en
P2093
H Kawasaki
S Kawashima
P2860
P304
P3181
P356
10.1101/GAD.12.15.2263
P407
P577
1998-08-01T00:00:00Z