IRAK: a kinase associated with the interleukin-1 receptor
about
Plant and animal pathogen recognition receptors signal through non-RD kinasesCloning of a novel receptor subunit, AcPL, required for interleukin-18 signalingThe kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathwayIRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) familyECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathwayIL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cellsFunctional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirementsT6BP, a TRAF6-interacting protein involved in IL-1 signalingIRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stabilityRegulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanismsRBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradationInterleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosolCharacterization of Pellino2, a substrate of IRAK1 and IRAK4Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activationEssential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunityIRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine productionSIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signalingNF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176A family of human receptors structurally related to Drosophila TollNF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complexMolecular determinants of NF-kappaB-inducing kinase actionCD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cellsOverexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaBIRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinaseReceptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transductionRaf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activationMEK5, a new target of the atypical protein kinase C isoforms in mitogenic signalingTransactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathwaySignaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domainDICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcriptionThe atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathwayLys63-linked polyubiquitination of IRAK-1 is required for interleukin-1 receptor- and toll-like receptor-mediated NF-kappaB activationRecruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory proteinTumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)
P2860
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P2860
IRAK: a kinase associated with the interleukin-1 receptor
description
1996 nî lūn-bûn
@nan
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
IRAK: a kinase associated with the interleukin-1 receptor
@ast
IRAK: a kinase associated with the interleukin-1 receptor
@en
IRAK: a kinase associated with the interleukin-1 receptor
@en-gb
IRAK: a kinase associated with the interleukin-1 receptor
@nl
type
label
IRAK: a kinase associated with the interleukin-1 receptor
@ast
IRAK: a kinase associated with the interleukin-1 receptor
@en
IRAK: a kinase associated with the interleukin-1 receptor
@en-gb
IRAK: a kinase associated with the interleukin-1 receptor
@nl
prefLabel
IRAK: a kinase associated with the interleukin-1 receptor
@ast
IRAK: a kinase associated with the interleukin-1 receptor
@en
IRAK: a kinase associated with the interleukin-1 receptor
@en-gb
IRAK: a kinase associated with the interleukin-1 receptor
@nl
P921
P3181
P1433
P1476
IRAK: a kinase associated with the interleukin-1 receptor
@en
P304
P3181
P356
10.1126/SCIENCE.271.5252.1128
P407
P577
1996-02-01T00:00:00Z