Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells
about
Polarised expression of human intestinal N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin) alpha and beta subunits in Madin-Darby canine kidney cellsIdentification of the cysteine residues implicated in the formation of alpha 2 and alpha/beta dimers of rat meprinMeprins, membrane-bound and secreted astacin metalloproteinasesThe astacin family of metalloendopeptidasesThe metzincins--topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidasesHeterologously overexpressed, affinity-purified human meprin alpha is functionally active and cleaves components of the basement membrane in vitroActivation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating systemSecretion of human meprin from intestinal epithelial cells depends on differential expression of the alpha and beta subunitsThe metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesionCOOH-terminal proteolytic processing of secreted and membrane forms of the alpha subunit of the metalloprotease meprin A. Requirement of the I domain for processing in the endoplasmic reticulum.Predicted seminal astacin-like protease is required for processing of reproductive proteins in Drosophila melanogaster.Meprinα transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migrationProinterleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation.Handling Metalloproteinases.Human N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase (human meprin): genomic structure of the alpha and beta subunits.N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase beta (human meprinbeta). A 13-amino-acid sequence is required for proteolyticprocessing and subsequent secretion.C-cytosolic and transmembrane domains of the N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase alpha subunit (human meprin alpha) are essential for its retention in the endoplasmic reticulum and C-terminal processing.Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin.Expression of the alpha subunit of PABA peptide hydrolase (EC 3.4.24.18) in MDCK cells. Synthesis and secretion of an enzymatically inactive homodimer.cDNA cloning, bacterial expression, in vitro renaturation and affinity purification of the zinc endopeptidase astacin.Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase.
P2860
Q24310747-7E1D3C74-7315-469F-8D18-082826F6367EQ24529873-23D8726C-30B2-4923-84BF-1DF98703322AQ24646365-77DAAA70-72E3-492B-83F1-D001EA91D7C3Q24675114-CBDEBBAB-899E-4B2F-BA51-830FDEBAAFBDQ24675153-F0573DC4-0877-4C37-A282-C90E199E95D2Q28141880-CCA185E2-FC4B-4786-9F5B-174E04023863Q28218647-3422F7F0-8758-43C4-A3E9-4258466B91F8Q28294813-A043C5EA-B6E4-4EC1-ADC3-6FDDADE82E11Q33334334-096C7995-2E92-4D0A-8752-DF18C3E9F0B8Q34320862-C9BE6F8E-C14D-47AF-AABC-F76A8C5346AAQ35214726-E1F3725A-70B5-4906-AAEB-11C718FA2BEDQ36318836-8BDCC82C-47F0-433F-B9B3-0E7F5097EB1BQ36968427-55161314-850A-4E18-BB2B-A84A3E8B23A1Q38719790-EC56C8CE-F64C-4C8E-B7D8-E0829F7FCE5BQ40902489-B7B826FF-1F9B-494E-80EC-FEF520CF1DE2Q40958722-9C0BDBCB-3F26-47BF-991C-FBE9E170767CQ41096220-012781CD-9E35-4935-9AE4-B56F7FB33B22Q41325258-6B616FD4-2690-4B6B-88D0-E4454D3E5BE0Q41509301-B5985BD0-CB67-42A2-8FBF-44F262EC1A9DQ42995369-AD925066-BFB8-4DE9-8033-C60633D5F8A6Q52229363-0E343E74-E1FD-4FF4-A09B-59D5F296A804
P2860
Cloning of the PABA peptide hydrolase alpha subunit (PPH alpha) from human small intestine and its expression in COS-1 cells
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@ast
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en-gb
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@nl
type
label
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@ast
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en-gb
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@nl
prefLabel
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@ast
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en-gb
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@nl
P2093
P2860
P1433
P1476
Cloning of the PABA peptide hy ...... its expression in COS-1 cells
@en
P2093
E Dumermuth
E E Sterchi
J A Eldering
J Grünberg
P2860
P304
P356
10.1016/0014-5793(93)80421-P
P407
P577
1993-12-13T00:00:00Z