Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
about
Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting proteinPhosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domainNon-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptorDistinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domainsInteraction of p85 subunit of PI 3-kinase with insulin and IGF-1 receptors analysed by using the two-hybrid systemSH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinaseCell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments.Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferationGrb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its functionIdentification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signalingNovel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiationThe signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiationRe-engineering the target specificity of the insulin receptor by modification of a PTB domain binding site14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent mannerTyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptorInteraction of insulin receptor substrate-2 (IRS-2) with the insulin and insulin-like growth factor I receptors. Evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2Evidence for a differential interaction of SHC and the insulin receptor substrate-1 (IRS-1) with the insulin-like growth factor-I (IGF-I) receptor in the yeast two-hybrid systemGrowth hormone, interferon-gamma, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signalingInteraction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activationIdentification of the rat adapter Grb14 as an inhibitor of insulin actionsIdentification of the APS protein as a novel insulin receptor substrateRecombinant human insulin receptor substrate-1 protein. Tyrosine phosphorylation and in vitro binding of insulin receptor kinaseIdentification of Stat 5B as a substrate of the insulin receptor.IRS pleckstrin homology domains bind to acidic motifs in proteins.Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signalingInsulin-like growth factor I synergizes with interleukin 4 for hematopoietic cell proliferation independent of insulin receptor substrate expression.The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipidsMetabolic syndrome and insulin resistance: underlying causes and modification by exercise training.Growth and survival signals transmitted via two distinct NPXY motifs within leukocyte tyrosine kinase, an insulin receptor-related tyrosine kinase.The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocationIncreased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs.Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling.Regulation of the PI3K/AKT Pathway and Fuel Utilization During Primate Torpor in the Gray Mouse Lemur, Microcebus murinus.Protection of epithelial cells by keratinocyte growth factor signalingInsulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif.Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking.Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system.The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein.Identification of a novel negative regulator of activin/nodal signaling in mesendodermal formation of Xenopus embryos.
P2860
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P2860
Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Characterization of an interac ...... by using the two-hybrid system
@ast
Characterization of an interac ...... by using the two-hybrid system
@en
Characterization of an interac ...... by using the two-hybrid system
@en-gb
Characterization of an interac ...... by using the two-hybrid system
@nl
type
label
Characterization of an interac ...... by using the two-hybrid system
@ast
Characterization of an interac ...... by using the two-hybrid system
@en
Characterization of an interac ...... by using the two-hybrid system
@en-gb
Characterization of an interac ...... by using the two-hybrid system
@nl
prefLabel
Characterization of an interac ...... by using the two-hybrid system
@ast
Characterization of an interac ...... by using the two-hybrid system
@en
Characterization of an interac ...... by using the two-hybrid system
@en-gb
Characterization of an interac ...... by using the two-hybrid system
@nl
P2093
P2860
P3181
P356
P1476
Characterization of an interac ...... by using the two-hybrid system
@en
P2093
T A Gustafson
T J O'Neill
P2860
P304
P3181
P356
10.1128/MCB.14.10.6433
P407
P577
1994-10-01T00:00:00Z