Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
about
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humansCharacterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factorThe Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGFOligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1The elucidation of novel SH2 binding sites on PLD2Structural basis for Rab GTPase activation by VPS9 domain exchange factorsC3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteinsHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorPhosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivoSos-mediated activation of rac1 by p66shcThe phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptorSH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerCatalytic competence of the Ras-GEF domain of hSos1 requires intra-REM domain interactions mediated by phenylalanine 577The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signalingMolecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cellsIdentification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptorBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerSubsets of epidermal growth factor receptors during activation and endocytosisDifferential interactions of human Sos1 and Sos2 with Grb2Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid systemBcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayRegulation of Sos activity by intramolecular interactions.Salmonella type III secretion effector SlrP is an E3 ubiquitin ligase for mammalian thioredoxinN terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domainsR-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrationsThe neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Kinectin is a key effector of RhoG microtubule-dependent cellular activityClathrin-mediated endocytosis of MUC1 is modulated by its glycosylation stateStathmin interaction with a putative kinase and coiled-coil-forming protein domainsProtein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cellsIdentification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimerac-Abl kinase regulates the protein binding activity of c-CrkThe endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brainShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsCRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor-induced activation of Ras in PC12 cellsGRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulationHuman securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinaseTyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activationCloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras
P2860
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P2860
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
description
1993 nî lūn-bûn
@nan
1993 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@ast
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en-gb
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@nl
type
label
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@ast
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en-gb
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@nl
prefLabel
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@ast
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en-gb
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@nl
P2093
P356
P1433
P1476
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2
@en
P2093
D Bar-Sagi
J H Camonis
J Schlessinger
L van Aelst
M H Wigler
P304
P356
10.1126/SCIENCE.8493579
P407
P577
1993-05-28T00:00:00Z