Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
about
Warburg effect and translocation-induced genomic instability: two yeast models for cancer cellsTitanium dioxide (TiO2) nanoparticles preferentially induce cell death in transformed cells in a Bak/Bax-independent fashionA precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancersThe function of APC/CCdh1 in cell cycle and beyondPremature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalingThe p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Identification of renox, an NAD(P)H oxidase in kidneyOverexpression of MYC causes p53-dependent G2 arrest of normal fibroblastsSET-related cell division autoantigen-1 (CDA1) arrests cell growthRole for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeresTBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescenceThe telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis.Physical and functional interaction between PML and TBX2 in the establishment of cellular senescenceNek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblastsThe emerging importance of group II PAKsHuman SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiationDynamic regulation of p53 subnuclear localization and senescence by MORC3Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsCARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNAIncreased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanismRab23 negatively regulates Gli1 transcriptional factor in a Su(Fu)-dependent mannerYPEL3, a p53-regulated gene that induces cellular senescenceConstitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescenceReciprocal regulation of p53 and malic enzymes modulates metabolism and senescenceThe CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradationLoss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescenceRegulation of cellular response to oncogenic and oxidative stress by Seladin-1Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cellsDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescenceING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylationc-Jun regulates cell cycle progression and apoptosis by distinct mechanismsGerm line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation
P2860
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P2860
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
description
1997 nî lūn-bûn
@nan
1997 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի մարտին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@ast
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en-gb
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@nl
type
label
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@ast
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en-gb
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@nl
prefLabel
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@ast
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en-gb
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@nl
P2093
P921
P3181
P1433
P1476
Oncogenic ras provokes prematu ...... cumulation of p53 and p16INK4a
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)81902-9
P407
P577
1997-03-07T00:00:00Z