DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.
about
Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activityEffects of MdmX on Mdm2-mediated downregulation of pRBRegulation of MDMX nuclear import and degradation by Chk2 and 14-3-3.14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activationPhosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 bindingMdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligaseMDMX regulation of p53 response to ribosomal stressAn essential function of the extreme C-terminus of MDM2 can be provided by MDMXRibosomal proteins as unrevealed caretakers for cellular stress and genomic instabilityDeubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in transFragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2Structural basis of how stress-induced MDMX phosphorylation activates p53Hdmx modulates the outcome of p53 activation in human tumor cellsFunctional activation of mutant p53V172F by platinum analogs in cisplatin-resistant human tumor cells is dependent on serine-20 phosphorylationRegulating the p53 pathway: in vitro hypotheses, in vivo veritasMDM4 (MDMX) and its Transcript Variants.Cancer susceptibility polymorphism of p53 at codon 72 affects phosphorylation and degradation of p53 protein.Mutation analysis of the MDM4 gene in German breast cancer patientsThe regulation of the p53-mediated stress response by MDM2 and MDM4.Controlling the Mdm2-Mdmx-p53 Circuit.The p53 orchestra: Mdm2 and Mdmx set the toneSpontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver.c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation.14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage.Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-MycMdmX protein is essential for Mdm2 protein-mediated p53 polyubiquitination.Abnormal MDMX degradation in tumor cells due to ARF deficiencyQuantitative analyses reveal the importance of regulated Hdmx degradation for p53 activationHypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.Casein kinase 1α regulates an MDMX intramolecular interaction to stimulate p53 binding.Regulation of MDMX expression by mitogenic signaling.Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinasesAMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity.Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.Apoptosis in leukemias: regulation and therapeutic targeting.
P2860
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P2860
DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
DNA damage-induced phosphoryla ...... for Mdm2-dependent degradation
@nl
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@ast
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en-gb
type
label
DNA damage-induced phosphoryla ...... for Mdm2-dependent degradation
@nl
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@ast
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en-gb
prefLabel
DNA damage-induced phosphoryla ...... for Mdm2-dependent degradation
@nl
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@ast
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en-gb
P2093
P2860
P921
P1476
DNA damage-induced phosphoryla ...... or Mdm2-dependent degradation.
@en
P2093
Aart G Jochemsen
Amina Teunisse
Ayumi Nota
Carol Prives
Domenico Migliorini
Issay Kitabayashi
Kenji Kashima
Koji Okamoto
Michiko Ishida
Satomi Yamazaki
P2860
P304
P356
10.1128/MCB.25.21.9608-9620.2005
P407
P577
2005-11-01T00:00:00Z