Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control
about
Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachmentMitotic control of kinetochore-associated dynein and spindle orientation by human SpindlyBeclin-1 is required for chromosome congression and proper outer kinetochore assembly.Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpointZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survivalKNL1: bringing order to the kinetochoreDistinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosisZwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint.Sos7, an essential component of the conserved Schizosaccharomyces pombe Ndc80-MIND-Spc7 complex, identifies a new family of fungal kinetochore proteinsDrosophila Mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint.Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Topoisomerase IIα in chromosome instability and personalized cancer therapy.Candidate genes contributing to the aggressive phenotype of mantle cell lymphoma.The KMN protein network--chief conductors of the kinetochore orchestraThe Ndc80 complex: hub of kinetochore activity.Making an effective switch at the kinetochore by phosphorylation and dephosphorylation.Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.Spindle assembly checkpoint proteins are positioned close to core microtubule attachment sites at kinetochores.A quantitative systems view of the spindle assembly checkpoint.Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression.Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.Mitosis as an anti-cancer drug target.Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.Overexpression of androgen receptor enhances the binding of the receptor to the chromatin in prostate cancer.Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues.CENP-A Ubiquitylation Is Inherited through Dimerization between Cell DivisionsOverexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins.Bioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer.
P2860
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P2860
Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@ast
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en-gb
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@nl
type
label
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@ast
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en-gb
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@nl
prefLabel
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@ast
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en-gb
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@nl
P2093
P2860
P356
P1433
P1476
Hec1 sequentially recruits Zwi ...... and spindle checkpoint control
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1209687
P407
P577
2006-11-02T00:00:00Z
P5875
P6179
1025342268