Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo. - Wikidata - awgldk - TriplyDB

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.

http://www.wikidata.org/entity/Q36944217

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Deficient spindle assembly checkpoint in multiple myeloma Proinvasion metastasis drivers in early-stage melanoma are oncogenes.MTBP plays a crucial role in mitotic progression and chromosome segregation Chromosomal instability and cancer: a complex relationship with therapeutic potential MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation Transcriptional control of mitosis: deregulation and cancer Alp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.Transgenic, inducible RNAi in megakaryocytes and platelets in mice.Effect of NDC80 in human hepatocellular carcinoma Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program.Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.Mitotic chromosomal instability and cancer: mouse modelling of the human disease.Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers.Chromosome missegregation causes colon cancer by APC loss of heterozygosity.Macrophages facilitate coal tar pitch extract-induced tumorigenic transformation of human bronchial epithelial cells mediated by NF-κB.Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability--an implication in aneuploid human tumors.Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation Role of NEK2A in human cancer and its therapeutic potentials.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Chromosomal instability as a prognostic marker in cervical cancer.Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression.Overexpression of NDC80 is correlated with prognosis of pancreatic cancer and regulates cell proliferation.Losing balance: the origin and impact of aneuploidy in cancer Coiled-coil networking shapes cell molecular machinery Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas.Aneuploidy in health, disease, and aging.Upregulation of colonic and hepatic tumor overexpressed gene is significantly associated with the unfavorable prognosis marker of human hepatocellular carcinoma.Hec1-dependent cyclin B2 stabilization regulates the G2-M transition and early prometaphase in mouse oocytes Cancer karyotypes: survival of the fittest 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells.Chromosomes and cancer cells.Mechanisms of chromosomal instability.Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1.An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis New insights into the troubles of aneuploidy The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy.

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P2860

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo.

http://www.wikidata.org/entity/Q36944217

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.

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type

label

Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.

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prefLabel

Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.

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PNAS.0803504105

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Proceedings of the National Academy of Sciences of the United States of America

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Hec1 overexpression hyperactiv ...... duces tumor formation in vivo.

@en

P2093

Elena Diaz-Rodríguez

http://www.w3.org/2001/XMLSchema#string

Juan-Manuel Schvartzman

http://www.w3.org/2001/XMLSchema#string

Robert Benezra

http://www.w3.org/2001/XMLSchema#string

Rocio Sotillo

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of two novel components of the human NDC80 kinetochore complex

Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore

The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment

HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control

Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

Retinoblastoma protein enhances the fidelity of chromosome segregation mediated by hsHec1p

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment

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16719-16724

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scholarly article

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10.1073/PNAS.0803504105

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43

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105

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18940925

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2570608

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