Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor
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Nutritional Signaling via Free Fatty Acid ReceptorsPharmacology and physiology of gastrointestinal enteroendocrine cellsThe Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptorsPerspectives on the therapeutic potential of short-chain fatty acid receptorsFree fatty acid receptors: structural models and elucidation of ligand binding interactions.A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional BiasDrugs or diet?--Developing novel therapeutic strategies targeting the free fatty acid family of GPCRsThe pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismMinireview: The effects of species ortholog and SNP variation on receptors for free fatty acids.The therapeutic potential of GPR43: a novel role in modulating metabolic health.Treatment of type 2 diabetes by free Fatty Acid receptor agonists.Free fatty acid receptors as therapeutic targets for the treatment of diabetes.The Pharmacology and Function of Receptors for Short-Chain Fatty Acids.Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models.Polymorphic Variation in FFA Receptors: Functions and Consequences.Key Questions for Translation of FFA Receptors: From Pharmacology to Medicines.Anti-Inflammatory and Insulin-Sensitizing Effects of Free Fatty Acid Receptors.Application of GPCR Structures for Modelling of Free Fatty Acid Receptors.The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment.Pharmacological properties of acid N-thiazolylamide FFA2 agonists.Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands.A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35.Using Biosensors to Study Free Fatty Acid Receptor Pharmacology and Function.Ligands at the Free Fatty Acid Receptors 2/3 (GPR43/GPR41).Bioimaging, cellular uptake and dynamics in living cells of a lipophilic fluorescent benzothiadiazole at low temperature (4 °C)
P2860
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P2860
Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor
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2013 nî lūn-bûn
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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2013 թվականի հունիսին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年論文
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2013年论文
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name
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@ast
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en-gb
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@nl
type
label
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@ast
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en-gb
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@nl
prefLabel
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@ast
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en-gb
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@nl
P2093
P2860
P921
P3181
P356
P1476
Defining the molecular basis f ...... FFA2 free fatty acid receptor
@en
P2093
Amanda E Mackenzie
Anna Mette Hansen
Brian D Hudson
Elisabeth Christiansen
Hannah Murdoch
Irina G Tikhonova
Maria E Due-Hansen
Richard J Ward
Rudi Marquez
Sunil K Pandey
P2860
P304
P3181
P356
10.1074/JBC.M113.455337
P407
P577
2013-06-14T00:00:00Z