cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus - Wikidata - awgldk - TriplyDB

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus

http://www.wikidata.org/entity/Q24339465

about

Small molecules in the treatment of systemic lupus erythematosus Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection T cells as a therapeutic target in SLE.cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.cAMP-responsive element modulator α (CREMα) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE).T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunity.Cyclic AMP-Responsive Element Modulator α Polymorphisms Are Potential Genetic Risks for Systemic Lupus Erythematosus.cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).The cAMP response element modulator (CREM) regulates TH2 mediated inflammation Whole-genome transcription and DNA methylation analysis of peripheral blood mononuclear cells identified aberrant gene regulation pathways in systemic lupus erythematosus.cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and disease.cAMP responsive element modulator: a critical regulator of cytokine production cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance Gene-function studies in systemic lupus erythematosus.Gene expression and regulation in systemic lupus erythematosus.Epigenetic dysregulation in systemic lupus erythematosus.Critical role of DNA methylation in the pathogenesis of systemic lupus erythematosus: new advances and future challenges.Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells.Epigenetics in SLE.Restoring regulation - IL-2 therapy in systemic lupus erythematosus.CREM Alpha Enhances IL-21 Production in T Cells In Vivo and In Vitro.Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective.Translating epigenetics into clinic: focus on lupus.The role of CaMK4 in immune responses.IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation.TNFAIP3 downregulation mediated by histone modification contributes to T-cell dysfunction in systemic lupus erythematosus.Calcium/Calmodulin Kinase IV Controls the Function of Both T Cells and Kidney Resident Cells Effects of Major Epigenetic Factors on Systemic Lupus Erythematosus

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cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus

http://www.wikidata.org/entity/Q24339465

description

2011 nî lūn-bûn

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2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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cAMP-responsive element modula ...... n systemic lupus erythematosus

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cAMP-responsive element modula ...... n systemic lupus erythematosus

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cAMP-responsive element modula ...... n systemic lupus erythematosus

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cAMP-responsive element modula ...... n systemic lupus erythematosus

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JBC.M111.299339

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Journal of Biological Chemistry

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cAMP-responsive element modula ...... n systemic lupus erythematosus

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George C Tsokos

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Thomas Rauen

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A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

Cell-type-specific epigenetic marking of the IL2 gene at a distal cis-regulatory region in competent, nontranscribing T-cells

MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity

The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus

The genetics and epigenetics of autoimmune diseases.

Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond.

The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunity

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10.1074/JBC.M111.299339

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50

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286

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Christian M Hedrich

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21976679

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