Functional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 protein
about
A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infectionPosttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localizeRole of herpes simplex virus 1 immediate early protein ICP22 in viral nuclear egress.The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is presentGlycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins.Posttranslational processing of infected cell protein 22 mediated by viral protein kinases is sensitive to amino acid substitutions at distant sites and can be cell-type specificProducts of US22 genes M140 and M141 confer efficient replication of murine cytomegalovirus in macrophages and spleenHerpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functionscdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factorMutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus.The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22.HSV-1-based vectors for gene therapy of neurological diseases and brain tumors: part I. HSV-1 structure, replication and pathogenesis.A wide extent of inter-strain diversity in virulent and vaccine strains of alphaherpesviruses.An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0.U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.Herpes simplex virus 1 ICP22 inhibits the transcription of viral gene promoters by binding to and blocking the recruitment of P-TEFbU(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions.Sequence variation in the herpes simplex virus U(S)1 ocular virulence determinant.Herpes Simplex Virus 1 (HSV-1) ICP22 protein directly interacts with cyclin-dependent kinase (CDK)9 to inhibit RNA polymerase II transcription elongationThe immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo.Herpes simplex virus immediate-early protein ICP22 triggers loss of serine 2-phosphorylated RNA polymerase IIConserved herpesvirus protein kinases.The interaction of herpes simplex virus 1 regulatory protein ICP22 with the cdc25C phosphatase is enabled in vitro by viral protein kinases US3 and UL13.Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.Roles of p53 in herpes simplex virus 1 replication.The role of cdc2 in the expression of herpes simplex virus genes.Origin of expression of the herpes simplex virus type 1 protein U(S)1.5.Herpes simplex virus 1 ICP22 but not US 1.5 is required for efficient acute replication in mice and VICE domain formation.Identification of sequences in herpes simplex virus type 1 ICP22 that influence RNA polymerase II modification and viral late gene expression.ICP0 gene expression is a herpes simplex virus type 1 apoptotic triggerThe products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells.
P2860
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P2860
Functional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 protein
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@ast
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en-gb
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@nl
type
label
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@ast
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en-gb
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@nl
prefLabel
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@ast
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en-gb
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@nl
P2860
P1433
P1476
Functional anatomy of herpes s ...... l protein 22 and US1.5 protein
@en
P2093
P2860
P304
P407
P577
1999-05-01T00:00:00Z