Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.
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Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cellsInactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expressionHerpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complexMapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptidesRole of ND10 nuclear bodies in the chromatin repression of HSV-1Bovine Herpes Virus 1 (BHV-1) and Herpes Simplex Virus Type 1 (HSV-1) Promote Survival of Latently Infected Sensory Neurons, in Part by Inhibiting ApoptosisAn Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4Nucleocytoplasmic shuttling of the HSV-2 serine/threonine kinase Us3Role of chromatin during herpesvirus infections.Towards an understanding of the herpes simplex virus type 1 latency-reactivation cycleICP0 inhibits the decrease of HSV amplicon-mediated transgene expression.The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription.Herpes simplex virus protein kinases US3 and UL13 modulate VP11/12 phosphorylation, virion packaging, and phosphatidylinositol 3-kinase/Akt signaling activityHerpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functionsProbing phosphorylation-dependent protein interactions within functional domains of histone deacetylase 5 (HDAC5).Histone deacetylase inhibitors induce reactivation of herpes simplex virus type 1 in a latency-associated transcript-independent manner in neuronal cellsThe CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.A pre-immediate-early role for tegument ICP0 in the proteasome-dependent entry of herpes simplex virusThe checkpoints of viral gene expression in productive and latent infection: the role of the HDAC/CoREST/LSD1/REST repressor complexBarrier to auto integration factor becomes dephosphorylated during HSV-1 Infection and Can Act as a host defense by impairing viral DNA replication and gene expressionHerpes simplex virus 1 protein kinase Us3 and major tegument protein UL47 reciprocally regulate their subcellular localization in infected cells.Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma.Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene.Identification of a physiological phosphorylation site of the herpes simplex virus 1-encoded protein kinase Us3 which regulates its optimal catalytic activity in vitro and influences its function in infected cells.Human cytomegalovirus pUL97 regulates the viral major immediate early promoter by phosphorylation-mediated disruption of histone deacetylase 1 binding.The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem.Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1.Regulation of the catalytic activity of herpes simplex virus 1 protein kinase Us3 by autophosphorylation and its role in pathogenesis.Histone deacetylases 1 and 2 are phosphorylated at novel sites during varicella-zoster virus infection.Histone Deacetylase Inhibitors Reduce the Number of Herpes Simplex Virus-1 Genomes Initiating Expression in Individual Cells.During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription.NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling.Promyelocytic leukemia-nuclear body proteins: herpesvirus enemies, accomplices, or both?Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases.Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation.
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Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on December 2003
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
@en
Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
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type
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Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
@en
Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
@nl
prefLabel
Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
@en
Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
@nl
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Herpes simplex virus 1 gene ex ...... e infected-cell protein no. 0.
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P2093
Alice P W Poon
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P304
12671-12678
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10.1128/JVI.77.23.12671-12678.2003
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P577
2003-12-01T00:00:00Z