Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer - Wikidata - awgldk - TriplyDB

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

http://www.wikidata.org/entity/Q24529066

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Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer.Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins.Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1 Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.Necdin, a p53-target gene, is an inhibitor of p53-mediated growth arrest.Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow.Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.Differential expression profiling analyses identifies downregulation of 1p, 6q, and 14q genes and overexpression of 6p histone cluster 1 genes as markers of recurrence in meningiomas.The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.Single-stranded DNA-binding proteins regulate the abundance of LIM domain and LIM domain-binding proteins.Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer).Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma.Aberrant expression of LMO4 induces centrosome amplification and mitotic spindle abnormalities in breast cancer cells.The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells.Drosophila LIM-only is a positive regulator of transcription during thoracic bristle development.LIM only 4 is overexpressed in late stage pancreas cancer LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer.Apoptotic cell death in neuroblastoma.LIM-domain-only proteins in cancer.LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.The LIM-only factor LMO4 regulates expression of the BMP7 gene through an HDAC2-dependent mechanism, and controls cell proliferation and apoptosis of mammary epithelial cells.E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer.LMO4 functions as a co-activator of neurogenin 2 in the developing cortex.LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression.SSBP2 is an in vivo tumor suppressor and regulator of LDB1 stability.Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm.The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.LIM domain only 4 protein promotes granulocyte colony-stimulating factor-induced signaling in neurons.Requirement for Lmo4 in the vestibular morphogenesis of mouse inner ear.Lmo4 in the nucleus accumbens regulates cocaine sensitivity LMO4 modulates proliferation and differentiation of 3T3-L1 preadipocytes.Impaired lactation in mice expressing dominant-negative FADD in mammary epithelium.Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1.¹H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complex.

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P2860

Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer

http://www.wikidata.org/entity/Q24529066

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2005 nî lūn-bûn

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Overexpression of LMO4 induces ...... poor outcome in breast cancer

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Andrew S Field

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Belinda Duscio

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Davendra Segara

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Eleanor Y M Sum

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Geoffrey J Lindeman

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Jane E Visvader

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Mary L Bath

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Robert L Sutherland

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P2860

Molecular cloning of LMO41, a new human LIM domain gene

The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma

Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice

Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting.

The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer.

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