Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
about
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanismStructural basis of HIV-1 resistance to AZT by excisionStable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnetMg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance.Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?Current perspectives on HIV-1 antiretroviral drug resistanceThe choreography of HIV-1 proteolytic processing and virion assemblyCrystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceHIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT InhibitorsN348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistanceHIV-1 polymerase inhibition by nucleoside analogs: cellular- and kinetic parameters of efficacy, susceptibility and resistance selectionA fossil record of zidovudine resistance in transmitted isolates of HIV-1Novel high-throughput screen identifies an HIV-1 reverse transcriptase inhibitor with a unique mechanism of actionMolecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutationsCovalent modification of human immunodeficiency virus type 1 p6 by SUMO-1.Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance.ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity.Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutationsThe Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.Genotypic testing for human immunodeficiency virus type 1 drug resistance.4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanismsDrug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.The "Connection" Between HIV Drug Resistance and RNase HThe M184V mutation reduces the selective excision of zidovudine 5'-monophosphate (AZTMP) by the reverse transcriptase of human immunodeficiency virus type 1Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.The level of reverse transcriptase (RT) in human immunodeficiency virus type 1 particles affects susceptibility to nonnucleoside RT inhibitors but not to lamivudineSelective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutationsFitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1.HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replicationRelationship between 3'-azido-3'-deoxythymidine resistance and primer unblocking activity in foscarnet-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase.
P2860
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P2860
Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@ast
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en-gb
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@nl
type
label
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@ast
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en-gb
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@nl
prefLabel
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@ast
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en-gb
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@nl
P2093
P2860
P1433
P1476
Selective excision of AZTMP by ...... cy virus reverse transcriptase
@en
P2093
P2860
P304
P356
10.1128/JVI.75.10.4832-4842.2001
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P577
2001-05-01T00:00:00Z