Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance - Wikidata - awgldk - TriplyDB

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

http://www.wikidata.org/entity/Q27657718

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K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism Structural basis of HIV-1 resistance to AZT by excision Common and unique features of viral RNA-dependent polymerases HIV-1 reverse transcription HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.A template-dependent dislocation mechanism potentiates K65R reverse transcriptase mutation development in subtype C variants of HIV-1 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms Preparation of DNA and RNA fragments containing guanine N(2)-thioalkyl tethers.Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors.The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.Identification and characterization of a novel HIV-1 nucleotide-competing reverse transcriptase inhibitor series.4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replication Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations.Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.In vitro resistance profile of the candidate HIV-1 microbicide drug dapivirine Replication-independent expression of anti-apoptosis marker genes in human peripheral blood mononuclear cells infected with the wild-type HIV-1 and reverse transcriptase variants Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.Characterization of HIV-1 Resistance to Tenofovir Alafenamide In Vitro.The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets.Modeling the functional state of the reverse transcriptase of hepatitis B virus and its application to probing drug-protein interaction.Lys66 residue as a determinant of high mismatch extension and misinsertion rates of HIV-1 reverse transcriptase.Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.Conformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study.Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.Vaginal microbicides and their delivery platforms.The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.K65R and K65A substitutions in HIV-1 reverse transcriptase enhance polymerase fidelity by decreasing both dNTP misinsertion and mispaired primer extension efficiencies.Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase.The glutamine side chain at position 91 on the β5a-β5b loop of human immunodeficiency virus type 1 reverse transcriptase is required for stabilizing the dNTP binding pocket.Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.Rilpivirine and Doravirine Have Complementary Efficacies Against NNRTI-Resistant HIV-1 Mutants.Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance.Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses.Fidelity of classwide-resistant HIV-2 reverse transcriptase and differential contribution of K65R to the accuracy of HIV-1 and HIV-2 reverse transcriptases.

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Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir Resistance

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2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Structural Basis for the Role ...... nism, and Tenofovir Resistance

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Structural Basis for the Role ...... nism, and Tenofovir Resistance

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Structural Basis for the Role ...... nism, and Tenofovir Resistance

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Structural Basis for the Role ...... nism, and Tenofovir Resistance

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JBC.M109.022525

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Journal of Biological Chemistry

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Structural Basis for the Role ...... nism, and Tenofovir Resistance

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Arthur D Clark

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Barbara L Gaffney

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Joy Y Feng

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Kalyan Das

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Roger A Jones

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Stefan G Sarafianos

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P2860

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

Coot: model-building tools for molecular graphics

Version 1.2 of the Crystallography and NMR system

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs

Mutated K65R recombinant reverse transcriptase of human immunodeficiency virus type 1 shows diminished chain termination in the presence of 2',3'-dideoxycytidine 5'-triphosphate and other drugs

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

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35092-100

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10.1074/JBC.M109.022525

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50

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