Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates
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Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent SarinSubstrate tunnels in enzymes: structure-function relationships and computational methodologyIs It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traitsContinuum simulations of acetylcholine diffusion with reaction-determined boundaries in neuromuscular junction models.Flexibility versus "rigidity" of the functional architecture of AChE active centerChemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase.Toxicological considerations of acetylcholinesterase reactivators.New Cinchona Oximes Evaluated as Reactivators of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Organophosphorus Compounds.Post-exposure treatment with the oxime RS194B rapidly reverses early and advanced symptoms in macaques exposed to sarin vapor.Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.Bioaccumulation and neurotoxicity of dithiopyridine herbicide in the brain of freshwater fish, Cyprinus carpio.Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation.HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.Variation of cholinesterase-based biosensor sensitivity to inhibition by organophosphate due to ionizing radiationKamishoyosan and Shakuyakukanzoto promote recovery from paclitaxel-induced neurite retraction in PC12 cells.Acetylcholinesterase: converting a vulnerable target to a template for antidotes and detection of inhibitor exposure.Reaction pathway and free-energy barrier for reactivation of dimethylphosphoryl-inhibited human acetylcholinesteraseProfiling cholinesterase adduction: a high-throughput prioritization method for organophosphate exposure samples.Effects of the total alkaloidal extract of Murraya koenigii leaf on oxidative stress and cholinergic transmission in aged mice.The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies.Visceral adipose tissue-derived serine protease inhibitor augments acetylcholine-induced relaxation via the inhibition of acetylcholine esterase activity in rat isolated mesenteric artery.Supplementation of Maternal Diets with Docosahexaenoic Acid and Methylating Vitamins Impacts Growth and Development of Fetuses from Malnourished Gilts
P2860
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P2860
Acetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonates
description
2003 nî lūn-bûn
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2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@ast
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en-gb
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@nl
type
label
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@ast
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en-gb
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@nl
prefLabel
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@ast
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en-gb
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@nl
P2093
P2860
P3181
P356
P1433
P1476
Acetylcholinesterase active ce ...... and enantiomeric phosphonates
@en
P2093
Elsa Reiner
Harvey A Berman
Palmer Taylor
Vera Simeon-Rudolf
Zoran Radić
Zrinka Kovarik
P2860
P3181
P356
10.1042/BJ20021862
P407
P577
2003-07-01T00:00:00Z