Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level
about
Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and designAcetylcholinesterase active centre and gorge conformations analysed by combinatorial mutations and enantiomeric phosphonatesα-Linolenic Acid, A Nutraceutical with Pleiotropic Properties That Targets Endogenous Neuroprotective Pathways to Protect against Organophosphate Nerve Agent-Induced NeuropathologyObservation of an arsenic adduct in an acetyl esterase crystal structureCrystal structure of human butyrylcholinesterase and of its complexes with substrate and productsCrystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun † , ‡Crystal Structures of Brain Group-VIII Phospholipase A2 in Nonaged Complexes with the Organophosphorus Nerve Agents Soman and Sarin † , ‡Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexesHuman Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent SarinThe crystal structure of the cephalosporin deacetylating enzyme acetyl xylan esterase bound to paraoxon explains the low sensitivity of this serine hydrolase to organophosphate inactivationStructure and function of an insect -carboxylesterase ( Esterase7) associated with insecticide resistanceA conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeStructures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interfaceA wrench in the works of human acetylcholinesterase: soman induced conformational changes revealed by molecular dynamics simulationsMatrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry.Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.N-acetylcholinesterase-induced apoptosis in Alzheimer's diseaseRate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior.Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthdayDevelopment of organophosphate hydrolase activity in a bacterial homolog of human cholinesteraseResolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches.Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by OrganophosphatesStudy of para-Quinone Methide Precursors toward the Realkylation of Aged Acetylcholinesterase.Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics.Flexibility versus "rigidity" of the functional architecture of AChE active centerStructure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agentsPolyclonal antibody to soman-tyrosine.Direct quantitation of methyl phosphonate adducts to human serum butyrylcholinesterase by immunomagnetic-UHPLC-MS/MS.Computational Studies on Acetylcholinesterases.Recent developments in structural studies on acetylcholinesterase.Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study.The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complexAbsolute free energy and entropy of a mobile loop of the enzyme acetylcholinesterase.Inactivation of acetylcholinesterase by various fluorophores.Pulmonary delivery of an aerosolized recombinant human butyrylcholinesterase pretreatment protects against aerosolized paraoxon in macaques.Structural insights into substrate traffic and inhibition in acetylcholinesteraseNovel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases.
P2860
Q21090062-2F437E26-09CA-4C78-AD50-6DBFE4FDDDB7Q24530004-C9C6A5AD-F92E-4FEB-ABD9-C410F9D2FCD0Q26777019-5929E192-48D9-44BB-9C6A-69258B5C70FDQ27639927-0E4C1812-694E-4441-BFCA-C50557BE8504Q27641694-1B71CA8D-3B1A-46D7-982E-58A1A6E090D0Q27644348-8E6BF6DE-8CC7-4915-9CC5-CE6AF7CB092FQ27654042-F6CC38EA-4BBA-4CD0-8B0E-2958777EBA76Q27655257-CD427438-0EC6-438D-B343-463BB7780652Q27658861-C3C8B648-E012-43BD-9D7B-E965E25290DBQ27666886-752A9E21-B091-4053-8833-D92FC9641ADCQ27678479-EE873747-CCBC-4F5B-A866-DC90FF3F7A2DQ27702043-0174D0BE-4089-4C85-A256-F7BF058F3BECQ27704889-6C5995A0-5EA9-47B0-A7C9-86682AA3BC34Q28546253-8824F579-C21A-417E-BD02-3C1C1FFDA178Q33267564-AC02AAD2-9077-420B-885B-0A6157614894Q33294201-0D73EF8A-00CA-4C87-AB86-4EBB46CBDB8EQ33337647-D609861A-AD10-4445-AE0D-DCCF9B9B7C1CQ33366506-BEA38A69-38BB-463F-AA72-B94650414583Q33431605-11CBD861-E392-4F41-ACC2-BA30A32AFC3CQ33498052-32AC2D0E-892B-4D9B-9BA5-4A8726A646EAQ33815485-DD0B9B21-65C9-4337-ADE3-03DA681F5A8FQ35215813-FFF962B1-9198-436C-9AC7-23A9CD0A0F68Q35572473-E23F43B1-8871-4BFD-A759-994A8CFCEC79Q36331614-6ED421BB-7995-4658-8E01-20A675CDDF1FQ36408620-04B0F127-3EF2-4EE2-8944-413B2089E32BQ36838929-41E10FA7-CA77-49C4-AEBB-FDB014F4212EQ36923752-CC8A942A-6A9B-4C42-A538-BE6A17A82EA8Q36931131-11FCF8FB-D20F-48FE-83E3-2123ED083998Q36937977-106E346E-7CD6-46F6-BBC7-DC94324EEF59Q37067404-3D136415-11F7-4559-A94C-A2AC52C10D92Q38441695-0A9F7636-A02D-4209-A98D-0F53DC5E33B1Q38630724-00458D87-C167-4194-B4B2-42CAE8D9913EQ39306292-916C5C9B-1AD9-466C-A144-F65E92E9BDABQ39900733-A073C853-58F5-4B51-AEE1-79A416C1F9FFQ39909419-51DC774E-36FF-489B-BCD1-CD91720DEB7EQ39980398-BF855198-DC62-40BC-9DC1-2953AC3AFDA7Q40243430-434E93FD-42B0-4132-9585-C8B37A2A0FA2Q41287188-8C400CD4-D3D9-49B1-B78F-F5C1C8F536FFQ41444745-C333C6A2-A57B-4016-87F8-83A87A237F91Q41554020-36584C36-9383-40A1-A9AA-0BAB89530DE5
P2860
Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Crystal structures of aged pho ...... n products at the atomic level
@ast
Crystal structures of aged pho ...... n products at the atomic level
@en
Crystal structures of aged pho ...... n products at the atomic level
@nl
type
label
Crystal structures of aged pho ...... n products at the atomic level
@ast
Crystal structures of aged pho ...... n products at the atomic level
@en
Crystal structures of aged pho ...... n products at the atomic level
@nl
prefLabel
Crystal structures of aged pho ...... n products at the atomic level
@ast
Crystal structures of aged pho ...... n products at the atomic level
@en
Crystal structures of aged pho ...... n products at the atomic level
@nl
P2093
P356
P1433
P1476
Crystal structures of aged pho ...... n products at the atomic level
@en
P2093
Greenblatt HM
Millard CB
Ordentlich A
Shafferman A
P304
P356
10.1021/BI982678L
P407
P577
1999-06-01T00:00:00Z