Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.
about
Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaClImpairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegenerationGlycerophosphocholine catabolism as a new route for choline formation for phosphatidylcholine synthesis by the Kennedy pathway.NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genesOrganophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegenerationIdentification of an insulin-regulated lysophospholipase with homology to neuropathy target esteraseDrosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin.Loss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutantsThe functional organisation of glia in the adult brain of Drosophila and other insects.Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration.What's new about osmotic regulation of glycerophosphocholineEffect of over-expression of neuropathy target esterase on mammalian cell proliferation.Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brainNeuropathy target esterase is required for adult vertebrate axon maintenanceMotor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster.Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of DrosophilaDelayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolismDevelopmental expression of drop-dead is required for early adult survival and normal body mass in Drosophila melanogasterstraightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.Regulation of phosphatidylcholine homeostasis by Sec14.Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish.CREB is required for cAMP/PKA signals upregulating neuropathy target esterase expression.Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and functionNeurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases.Probing mechanisms that underlie human neurodegenerative diseases in DrosophilaDiabetic larvae and obese flies-emerging studies of metabolism in Drosophila.Swiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila.Genetic ablation of calcium-independent phospholipase A2{gamma} leads to alterations in hippocampal cardiolipin content and molecular species distribution, mitochondrial degeneration, autophagy, and cognitive dysfunction.Drosophila as a model to study the role of glia in neurodegeneration.A review of neurotoxicity of microcystins.Silencing of drpr leads to muscle and brain degeneration in adult Drosophila.De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system.
P2860
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P2860
Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Loss of Swiss cheese/neuropath ...... lial death in adult Drosophila
@nl
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@ast
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@en
type
label
Loss of Swiss cheese/neuropath ...... lial death in adult Drosophila
@nl
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@ast
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@en
prefLabel
Loss of Swiss cheese/neuropath ...... lial death in adult Drosophila
@nl
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@ast
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@en
P2093
P2860
P921
P1476
Loss of Swiss cheese/neuropath ...... ial death in adult Drosophila.
@en
P2093
Alexandre Bettencourt da Cruz
Jakob-Andreas Tschäpe
Markus Moser
Max Mühlig-Versen
Paul Glynn
Reinhard Büttner
P2860
P304
P356
10.1523/JNEUROSCI.5097-04.2005
P407
P577
2005-03-01T00:00:00Z