Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice
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Loss of Swiss cheese/neuropathy target esterase activity causes disruption of phosphatidylcholine homeostasis and neuronal and glial death in adult Drosophila.Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoidsNeuropathy target esterase and its yeast homologue degrade phosphatidylcholine to glycerophosphocholine in living cells.NTE1-encoded phosphatidylcholine phospholipase b regulates transcription of phospholipid biosynthetic genesSpg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signalingOrganophosphate-induced changes in the PKA regulatory function of Swiss Cheese/NTE lead to behavioral deficits and neurodegenerationHepatocyte growth factor activator inhibitor type 1 (HAI-1) is required for branching morphogenesis in the chorioallantoic placentaIdentification of an insulin-regulated lysophospholipase with homology to neuropathy target esteraseLoss-of-function mutations in PNPLA6 encoding neuropathy target esterase underlie pubertal failure and neurological deficits in Gordon Holmes syndrome.Effect of over-expression of neuropathy target esterase on mammalian cell proliferation.Neuropathy target esterase is required for adult vertebrate axon maintenanceMotor neuron disease due to neuropathy target esterase mutation: enzyme analysis of fibroblasts from human subjects yields insights into pathogenesis.Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Delayed Induction of Human NTE (PNPLA6) Rescues Neurodegeneration and Mobility Defects of Drosophila swiss cheese (sws) Mutants.Development of structures and transport functions in the mouse placenta.Knockdown of Pnpla6 protein results in motor neuron defects in zebrafish.CREB is required for cAMP/PKA signals upregulating neuropathy target esterase expression.Glial expression of Swiss cheese (SWS), the Drosophila orthologue of neuropathy target esterase (NTE), is required for neuronal ensheathment and functionSwiss Cheese, a protein involved in progressive neurodegeneration, acts as a noncanonical regulatory subunit for PKA-C3.Spongiform pathology in mouse CNS lacking 'neuropathy target esterase' and cellular prion protein.Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila.Brain-specific deletion of neuropathy target esterase/swisscheese results in neurodegeneration.Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.Shortening and Improving the Embryonic Stem Cell Test through the Use of Gene Biomarkers of Differentiation.Neuropathy target esterase impairments cause Oliver-McFarlane and Laurence-Moon syndromes.Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era.Impaired embryonic development in glucose-6-phosphate dehydrogenase-deficient Caenorhabditis elegans due to abnormal redox homeostasis induced activation of calcium-independent phospholipase and alteration of glycerophospholipid metabolismNTE/PNPLA6 is expressed in mature Schwann cells and is required for glial ensheathment of Remak fibers.Kinetic interactions of a neuropathy potentiator (phenylmethylsulfonyl fluoride) with the neuropathy target esterase and other membrane bound esterases.Functional pathways altered after silencing Pnpla6 (the codifying gene of neuropathy target esterase) in mouse embryonic stem cells under differentiation.The destruction box is involved in the degradation of the NTE family proteins by the proteasome.Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish.
P2860
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P2860
Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Placental failure and impaired ...... target esterase-deficient mice
@ast
Placental failure and impaired ...... target esterase-deficient mice
@en
Placental failure and impaired ...... target esterase-deficient mice
@nl
type
label
Placental failure and impaired ...... target esterase-deficient mice
@ast
Placental failure and impaired ...... target esterase-deficient mice
@en
Placental failure and impaired ...... target esterase-deficient mice
@nl
prefLabel
Placental failure and impaired ...... target esterase-deficient mice
@ast
Placental failure and impaired ...... target esterase-deficient mice
@en
Placental failure and impaired ...... target esterase-deficient mice
@nl
P2093
P2860
P1476
Placental failure and impaired ...... target esterase-deficient mice
@en
P2093
Doris Kretzschmar
Kristina Vaupel
Markus Moser
Paul Glynn
Reinhard Buettner
Reinhart Kluge
P2860
P304
P356
10.1128/MCB.24.4.1667-1679.2004
P407
P577
2004-02-01T00:00:00Z