The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
about
Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKRRDE-4 preferentially binds long dsRNA and its dimerization is necessary for cleavage of dsRNA to siRNA.The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferationRAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infectionProduction of small RNAs by mammalian DicerMissense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull developmentRecombinant hTRBP and hPACT Modulate hAgo2-Catalyzed siRNA-Mediated Target RNA Cleavage In VitroThe role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimulidsRNA binding protein PACT/RAX in gene silencing, development and diseases.Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila.PACT/RAX regulates the migration of cerebellar granule neurons in the developing cerebellum.Expression of PACT is regulated by Sp1 transcription factor.Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT.The multiple functions of TRBP, at the hub of cell responses to viruses, stress, and cancer.The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development.Recent advances in the molecular pathogenesis of dystonia-plus syndromes and heredodegenerative dystonias.RAX is required for fly neuronal development and mouse embryogenesis.TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress.Biochemical analysis of PKR activation by PACT.Molecular pathways in dystonia.Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs.Understanding dystonia: diagnostic issues and how to overcome them.The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication.The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrestEssential role of PACT-mediated PKR activation in tunicamycin-induced apoptosis.The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/ MDA5 activation.Ribosomal protein L22 inhibits regulation of cellular activities by the Epstein-Barr virus small RNA EBER-1.Contribution of the two dsRBM motifs to the double-stranded RNA binding and protein interactions of PACT.Increased interaction between PACT molecules in response to stress signals is required for PKR activation.
P2860
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P2860
The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)
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2002 nî lūn-bûn
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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի օգոստոսին հրատարակված գիտական հոդված
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2002年の論文
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2002年論文
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2002年論文
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2002年論文
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2002年論文
@zh-mo
2002年論文
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2002年论文
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name
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@ast
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@en
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@nl
type
label
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@ast
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@en
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@nl
prefLabel
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@ast
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@en
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@nl
P2093
P2860
P3181
P356
P1433
P1476
The C-terminal, third conserve ...... dependent protein kinase (PKR)
@en
P2093
Brian Hutchins
Rekha C Patel
P2860
P304
P3181
P356
10.1042/BJ20020204
P407
P577
2002-08-15T00:00:00Z