Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities - Wikidata - awgldk - TriplyDB

Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities

Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities

http://www.wikidata.org/entity/Q24534960

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Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substrates Identification and characterization of human MUS81-MMS4 structure-specific endonuclease Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases Holliday junction binding activity of the human Rad51B protein Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions Identification of RecQL1 as a Holliday junction processing enzyme in human cell lines Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells RNA interference inhibition of Mus81 reduces mitotic recombination in human cells Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands REC, Drosophila MCM8, drives formation of meiotic crossovers.Hold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1 Nucleases in homologous recombination as targets for cancer therapy Crystal structure of the Mus81-Eme1 complex A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair A winged helix domain in human MUS81 binds DNA and modulates the endonuclease activity of MUS81 complexes Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.Opposing roles for DNA structure-specific proteins Rad1, Msh2, Msh3, and Sgs1 in yeast gene targeting.Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?Identification of nucleases and phosphatases by direct biochemical screen of the Saccharomyces cerevisiae proteome.RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells Happy Hollidays: 40th anniversary of the Holliday junction The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair Incision at hypoxanthine residues in DNA by a mammalian homologue of the Escherichia coli antimutator enzyme endonuclease V The Bloom's syndrome helicase suppresses crossing over during homologous recombination Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair Identification of a novel helicase activity unwinding branched DNAs from the hyperthermophilic archaeon, Pyrococcus furiosus.The RTR Complex Partner RMI2 and the DNA Helicase RTEL1 Are Both Independently Involved in Preserving the Stability of 45S rDNA Repeats in Arabidopsis thaliana.Biochemistry of Meiotic Recombination: Formation, Processing, and Resolution of Recombination Intermediates.Human MUS81-EME2 can cleave a variety of DNA structures including intact Holliday junction and nicked duplex.GEN1/Yen1 and the SLX4 complex: Solutions to the problem of Holliday junction resolution.Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Three structure-selective endonucleases are essential in the absence of BLM helicase in Drosophila.

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Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities

http://www.wikidata.org/entity/Q24534960

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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Holliday junction resolution i ...... stinct substrate specificities

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The EMBO Journal

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Holliday junction resolution i ...... stinct substrate specificities

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Angelos Constantinou

http://www.w3.org/2001/XMLSchema#string

Clare H McGowan

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Xiao-Bo Chen

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DNA end-joining catalyzed by human cell-free extracts

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae

Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae

Damage tolerance protein Mus81 associates with the FHA1 domain of checkpoint kinase Cds1

DNA replication meets genetic exchange: chromosomal damage and its repair by homologous recombination

The Bloom's syndrome gene product promotes branch migration of holliday junctions

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases.

A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease

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scholarly article

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2911834

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10.1093/EMBOJ/CDF554

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20

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21

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2002-10-01T00:00:00Z

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277385137

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12374758

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Holliday junction resolvase complex

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129086

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