Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells
about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesThe CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cellsNucleases in homologous recombination as targets for cancer therapyCrystal structure of the Mus81-Eme1 complexMus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates.Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.Effect of single-strand break on branch migration and folding dynamics of Holliday junctionsInhibition of Mus81 by siRNA enhances sensitivity to 5-FU in breast carcinoma cell lines.Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damageMus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structuresBloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stressEffect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women.Clinical relevance of the homologous recombination machinery in cancer therapy.Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders.A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilitiesResolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Gene expression profiles of single human mature oocytes in relation to age.Radiosensitisation of human colorectal cancer cells by ruthenium(II) arene anticancer complexes.Substrate specificity of the MUS81-EME2 structure selective endonuclease.Mechanistic basis for increased human gene targeting by promoterless vectors-roles of homology arms and Rad54 paralogs.SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair.Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathwayEpisomal high copy number maintenance of hairpin-capped DNA bearing a replication initiation region in human cells.The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction.Impact of non-homologous end-joining deficiency on random and targeted DNA integration: implications for gene targeting.Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4.Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein.The SMX DNA Repair Tri-nuclease.The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks.Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells.Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.Translational study identifies XPF and MUS81 as predictive biomarkers for oxaliplatin-based peri-operative chemotherapy in patients with esophageal adenocarcinoma.
P2860
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P2860
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells
description
2006 nî lūn-bûn
@nan
2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@ast
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en-gb
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@nl
type
label
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@ast
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en-gb
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@nl
prefLabel
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@ast
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en-gb
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@nl
P2093
P2860
P356
P1476
Haploinsufficiency of the Mus8 ...... s rereplication in human cells
@en
P2093
Aiko Kinomura
Kiyoshi Miyagawa
Mari Ishida
Mari Katsura
Takashi Hiyama
Takashi Yoshihara
Tetsuji Tonda
Toshimasa Asahara
P2860
P304
P356
10.1093/NAR/GKJ495
P407
P577
2006-02-02T00:00:00Z