X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.
about
Identification of an endogenous ligand bound to a native orphan nuclear receptorOrphan nuclear receptors in drug discoveryROR nuclear receptors: structures, related diseases, and drug discoveryMinireview: the role of nuclear receptors in photoreceptor differentiation and diseaseThe therapeutic potential of RORγ modulators in the treatment of human diseaseRole of Nuclear Receptors in Central Nervous System Development and Associated DiseasesStructural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombeActivation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional stateCombinations of protein-chemical complex structures reveal new targets for established drugsExamination of nuclear receptor expression in osteoblasts reveals Rorβ as an important regulator of osteogenesisGene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolismThe AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurineIdentification of an allosteric binding site for RORγt inhibition.Retinoic acid actions through mammalian nuclear receptors.Insights from biophysical studies on the role of polyunsaturated fatty acids for function of G-protein coupled membrane receptors.The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in DrosophilaThe crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeuticsNovel mechanism of nuclear receptor corepressor interaction dictated by activation function 2 helix determinants.Structural and functional insights into nuclear receptor signaling.REV-ERB and ROR nuclear receptors as drug targets.Retinoid-related Orphan Receptors (RORs): Roles in Cellular Differentiation and Development.Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolismRetinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo.Identification of natural RORγ ligands that regulate the development of lymphoid cellsThe REV-ERBs and RORs: molecular links between circadian rhythms and lipid homeostasis.Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activitySpecificity of receptor-ligand interactions and their effect on dimerisation as observed by electrospray mass spectrometry: bile acids form stable adducts to the RXRalpha.Using nondenaturing mass spectrometry to detect fortuitous ligands in orphan nuclear receptors.Adopting new orphans into the family of metabolic regulatorsEmerging roles of orphan nuclear receptors in regulation of innate immunity.The obesity-related pathology and Th17 cells.Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1.The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome.Amino acids important for ligand specificity of the human constitutive androstane receptor.The co-repressor hairless protects RORalpha orphan nuclear receptor from proteasome-mediated degradation.Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation.Mutation analysis and molecular modeling for the investigation of ligand-binding modes of GPR84.Retinoid-related orphan receptors (RORs): roles in cell survival, differentiation and disease.
P2860
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P2860
X-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.
description
2001 nî lūn-bûn
@nan
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
X-ray structure of the orphan ...... ain in the active conformation
@nl
X-ray structure of the orphan ...... in in the active conformation.
@ast
X-ray structure of the orphan ...... in in the active conformation.
@en
X-ray structure of the orphan ...... in in the active conformation.
@en-gb
type
label
X-ray structure of the orphan ...... ain in the active conformation
@nl
X-ray structure of the orphan ...... in in the active conformation.
@ast
X-ray structure of the orphan ...... in in the active conformation.
@en
X-ray structure of the orphan ...... in in the active conformation.
@en-gb
prefLabel
X-ray structure of the orphan ...... ain in the active conformation
@nl
X-ray structure of the orphan ...... in in the active conformation.
@ast
X-ray structure of the orphan ...... in in the active conformation.
@en
X-ray structure of the orphan ...... in in the active conformation.
@en-gb
P2093
P2860
P356
P1433
P1476
X-ray structure of the orphan ...... ain in the active conformation
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/20.21.5822
P407
P577
2001-11-01T00:00:00Z