about
Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexesX-ray structure of the orphan nuclear receptor RORbeta ligand-binding domain in the active conformation.Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoniStructural insight into arginine methylation by the mouse protein arginine methyltransferase 7: a zinc finger freezes the mimic of the dimeric state into a single active siteFunctional insights from high resolution structures of mouse protein arginine methyltransferase 6Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptorA new class of transcription initiation factors, intermediate between TATA box-binding proteins (TBPs) and TBP-like factors (TLFs), is present in the marine unicellular organism, the dinoflagellate Crypthecodinium cohnii.Three-dimensional models of estrogen receptor ligand binding domain complexes, based on related crystal structures and mutational and structure-activity relationship data.Residues in the ligand binding domain that confer progestin or glucocorticoid specificity and modulate the receptor transactivation capacity.The TBP-like factor: an alternative transcription factor in metazoa?Identification of an alternative ligand-binding pocket in the nuclear vitamin D receptor and its functional importance in 1alpha,25(OH)2-vitamin D3 signaling.The monomeric orphan nuclear receptor Schistosoma mansoni Ftz-F1 dimerizes specifically and functionally with the schistosome RXR homologue, SmRXR1.Antagonism in the human mineralocorticoid receptor.Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients.Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a recUnfaithfulness and promiscuity of a mutant androgen receptor in a hormone-refractory prostate cancer.The bromodomain revisited.Defining and characterizing protein surface using alpha shapes.Partial defects in transcriptional activity of two novel DAX-1 mutations in childhood-onset adrenal hypoplasia congenitaReappraisal of the Role of Heat Shock Proteins as Regulators of Steroid Receptor ActivitySequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identitiesA canonical structure for the ligand-binding domain of nuclear receptorsSpecific recognition of androgens by their nuclear receptor. A structure-function studyInvestigation of the binding interactions of progesterone using muteins of the human progesterone receptor ligand binding domain designed on the basis of a three-dimensional protein model
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jean-Marie Wurtz
@ast
Jean-Marie Wurtz
@en
Jean-Marie Wurtz
@es
Jean-Marie Wurtz
@nl
type
label
Jean-Marie Wurtz
@ast
Jean-Marie Wurtz
@en
Jean-Marie Wurtz
@es
Jean-Marie Wurtz
@nl
prefLabel
Jean-Marie Wurtz
@ast
Jean-Marie Wurtz
@en
Jean-Marie Wurtz
@es
Jean-Marie Wurtz
@nl
P1053
P-4652-2016
P106
P31
P496
0000-0003-2963-8617