Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control
about
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repairPPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpointsOncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathwayWip1 phosphatase: between p53 and MAPK kinases pathwaysWip-ing out cancerRegulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphataseSPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63Distinct phosphatases antagonize the p53 response in different phases of the cell cycleA chemical inhibitor of PPM1D that selectively kills cells overexpressing PPM1D.The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repairNuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase.WIP1 phosphatase as pharmacological target in cancer therapy.Expression of a homeostatic regulator, Wip1 (wild-type p53-induced phosphatase), is temporally induced by c-Jun and p53 in response to UV irradiation.Wild-type p53-induced Phosphatase 1 Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury.Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage responsePhosphatases in the cellular response to DNA damage.Deficiency of the tumor promoter gene wip1 induces insulin resistance.Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.The role of p53 in chemosensitivity and radiosensitivity.Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agentsPhosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 SystemWip1 phosphatase positively modulates dendritic spine morphology and memory processes through the p38MAPK signaling pathway.MicroRNAs, wild-type and mutant p53: more questions than answers.Regulation of the Wip1 phosphatase and its effects on the stress response.Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesisThe type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.Hormone-sensing cells require Wip1 for paracrine stimulation in normal and premalignant mammary epitheliumRestoration of Retarded Influenza Virus-specific Immunoglobulin Class Switch in Aged Mice.Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis.Phosphatase Wip1 in Immunity: An Overview and UpdateWip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality.Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication.Crosstalk between the DNA damage response pathway and microRNAs.WIP1 phosphatase is a critical regulator of adipogenesis through dephosphorylating PPARγ serine 112.Control of stress signaling in stem cells: crossroads of stem cells and cancer.Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation.
P2860
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P2860
Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control
description
2002 nî lūn-bûn
@nan
2002 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mice deficient for the wild-ty ...... nction, and cell cycle control
@ast
Mice deficient for the wild-ty ...... nction, and cell cycle control
@en
Mice deficient for the wild-ty ...... nction, and cell cycle control
@nl
type
label
Mice deficient for the wild-ty ...... nction, and cell cycle control
@ast
Mice deficient for the wild-ty ...... nction, and cell cycle control
@en
Mice deficient for the wild-ty ...... nction, and cell cycle control
@nl
prefLabel
Mice deficient for the wild-ty ...... nction, and cell cycle control
@ast
Mice deficient for the wild-ty ...... nction, and cell cycle control
@en
Mice deficient for the wild-ty ...... nction, and cell cycle control
@nl
P2093
P2860
P3181
P1476
Mice deficient for the wild-ty ...... nction, and cell cycle control
@en
P2093
Allan Bradley
Austin Cooney
Bonnie Nannenga
Cory Brayton
Dmitry V Bulavin
Innocent N Mbawuike
Lawrence A Donehower
Yongxin Zhang
P2860
P304
P3181
P356
10.1128/MCB.22.4.1094-1105.2002
P407
P577
2002-02-01T00:00:00Z