Distinct phosphatases antagonize the p53 response in different phases of the cell cycle - Wikidata - awgldk - TriplyDB

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

http://www.wikidata.org/entity/Q30578888

about

Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition Hypersensitivity to DNA damage in antephase as a safeguard for genome stability.PP4 is essential for germinal center formation and class switch recombination in mice Phosphatases reverse p53-mediated cell cycle checkpoints WIP1 phosphatase as pharmacological target in cancer therapy.Centromeric binding and activity of Protein Phosphatase 4 Fanconi anemia cells with unrepaired DNA damage activate components of the checkpoint recovery process.A novel mathematical model of ATM/p53/NF- κB pathways points to the importance of the DDR switch-off mechanisms RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.Utilizing G2/M retention effect to enhance tumor accumulation of active targeting nanoparticles.p53 regulation upon genotoxic stress: intricacies and complexities.Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit.Cisplatin induces HepG2 cell cycle arrest through targeting specific long noncoding RNAs and the p53 signaling pathway Wip1 phosphatase in breast cancer.FUCCI sensors: powerful new tools for analysis of cell proliferation.Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion.KMT Set7/9 affects genotoxic stress response via the Mdm2 axis.Altered Transcriptional Control Networks with Trans-Differentiation of Isogenic Mutant-KRas NSCLC Models.Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.The live cell DNA stain SiR-Hoechst induces DNA damage responses and impairs cell cycle progression.A limited number of double-strand DNA breaks is sufficient to delay cell cycle progression

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P2860

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

http://www.wikidata.org/entity/Q30578888

description

2014 nî lūn-bûn

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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2014 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

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2014年論文

@zh-mo

2014年論文

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2014年论文

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name

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@ast

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@en

type

label

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@ast

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@en

prefLabel

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@ast

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@en

P1433

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P356

PNAS.1322021111

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

@en

P2093

Dipanjan Chowdhury

http://www.w3.org/2001/XMLSchema#string

Emile E Voest

http://www.w3.org/2001/XMLSchema#string

Geert J P L Kops

http://www.w3.org/2001/XMLSchema#string

Melinda Aprelia

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P2860

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

TAO kinases mediate activation of p38 in response to DNA damage

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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scholarly article

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10.1073/PNAS.1322021111

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P433

20

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111

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René H. Medema

Indra A. Shaltiel

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2014-04-07T00:00:00Z

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24711418

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4034242

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