SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
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SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradationThe E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteinsDeletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Two Drosophila suppressors of cytokine signaling (SOCS) differentially regulate JAK and EGFR pathway activitiesNegative regulation of cytokine signaling and immune responses by SOCS proteinsThe role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerThe role of suppressors of cytokine signalling in human neoplasmsStructure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR DegradationStructural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin LigaseSuppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signalingAnalysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategyRbx2 regulates neuronal migration through different cullin 5-RING ligase adaptorsAgm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and developmentPim3 negatively regulates glucose-stimulated insulin secretionGenetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopeniaAnkyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradationIn vitro and in vivo effects of suppressor of cytokine signalling 7 knockdown in breast cancer: the influence on cellular response to hepatocyte growth factor.Suppressor of cytokine signalling-6 promotes neurite outgrowth via JAK2/STAT5-mediated signalling pathway, involving negative feedback inhibition.Array-comparative genomic hybridization reveals loss of SOCS6 is associated with poor prognosis in primary lung squamous cell carcinoma.Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish.Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins.MicroRNA-183-5p promotes the proliferation, invasion and metastasis of human pancreatic adenocarcinoma cells.SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function.Isotope coded protein labeling coupled immunoprecipitation (ICPL-IP): a novel approach for quantitative protein complex analysis from native tissueSOCS regulation of the JAK/STAT signalling pathway.Development of hydrocephalus in mice lacking SOCS7.Inputs and outputs of insulin receptor.The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.SOCS proteins in development and disease.Suppressors of cytokine signaling (SOCS) and type 2 diabetes.SOCS proteins in regulation of receptor tyrosine kinase signaling.Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.SOCS6 is a selective suppressor of receptor tyrosine kinase signaling.Cell regulation by phosphotyrosine-targeted ubiquitin ligases.Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins.
P2860
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P2860
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
description
2002 nî lūn-bûn
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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@ast
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@en
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@nl
type
label
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@ast
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@en
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@nl
prefLabel
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@ast
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@en
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@nl
P2093
P2860
P50
P921
P3181
P1476
SOCS-6 binds to insulin recept ...... xhibit mild growth retardation
@en
P2093
Danielle L Krebs
Jian-Guo Zhang
Kathy Hanzinikolas
Lisa M Connolly
Manuel Baca
Robyn Starr
Sandra E Nicholson
Steven Rakar
Warren S Alexander
P2860
P304
P3181
P356
10.1128/MCB.22.13.4567-4578.2002
P407
P577
2002-07-01T00:00:00Z