Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase. - Wikidata - awgldk - TriplyDB

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.

http://www.wikidata.org/entity/Q34650624

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Protein production and purification Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly WSB1: from homeostasis to hypoxia Molecular signaling involving intrinsically disordered proteins in prostate cancer The biology and mechanism of action of suppressor of cytokine signaling 3 Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation.The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases Targeting protein-protein interactions for therapeutic intervention: a challenge for the future.Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.Protein degradation machinery is present broadly during early development in the sea urchin.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Maize Elongin C interacts with the viral genome-linked protein, VPg, of Sugarcane mosaic virus and facilitates virus infection.Filamins but not Janus kinases are substrates of the ASB2α cullin-ring E3 ubiquitin ligase in hematopoietic cells.Structural assembly of cullin-RING ubiquitin ligase complexes.Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex Flexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitination.Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins.SOCS regulation of the JAK/STAT signalling pathway.Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif.Suppression of cytokine signaling: the SOCS perspective.The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.Inhibition of IL-6 family cytokines by SOCS3.Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity.The cullin protein family.

P2860

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P2860

Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase.

http://www.wikidata.org/entity/Q34650624

description

2006 nî lūn-bûn

@nan

2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

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2006年论文

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name

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@ast

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@en

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@nl

type

label

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@ast

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@en

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@nl

prefLabel

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@ast

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@en

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@nl

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PNAS.0601638103

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Crystal structure of the SOCS2 ...... cal SOCS box ubiquitin ligase.

@en

P2093

Alex N Bullock

http://www.w3.org/2001/XMLSchema#string

Judit E Debreczeni

http://www.w3.org/2001/XMLSchema#string

Michael Sundström

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

Design and application of a cytokine-receptor-based interaction trap

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C

The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Coot: model-building tools for molecular graphics

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103

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16675548

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crystal structure

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1472497

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