MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation - Wikidata - awgldk - TriplyDB

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

http://www.wikidata.org/entity/Q24537700

about

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents HDM2-binding partners: interaction with translation elongation factor EF1alpha.Negative regulation of p53 functions by Daxx and the involvement of MDM2 Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53 Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding Chfr is linked to tumour metastasis through the downregulation of HDAC1 Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1 A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2 The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation Corepressor MMTR/DMAP1 is involved in both histone deacetylase 1- and TFIIH-mediated transcriptional repression Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53 HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases Expanding the ubiquitin code through post-translational modification Mdm2 as a chromatin modifier The role of prostate tumor overexpressed 1 in cancer progression p53 Acetylation: Regulation and Consequences The promise and perils of HDAC inhibitors in neurodegeneration Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment Histone deacetylases and cancer Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro E2F1-mediated FOS induction in arsenic trioxide-induced cellular transformation: effects of global H3K9 hypoacetylation and promoter-specific hyperacetylation in vitro Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production Integrating genomics and proteomics data to predict drug effects using binary linear programming

P2860

Q24293712-F6EED457-5789-4268-99B9-D98EE3081638 Q24295165-1ADC4715-6D2A-449A-93A3-46293BD1FB49 Q24295186-1307B573-2513-433A-A517-51ED16D8F5B1 Q24297439-3E2549FB-04C5-4950-96AC-A28E1642FB8A Q24300548-5620CA77-94CA-4852-A316-797157B1A3E1 Q24303893-88E20038-7831-416F-BF66-A7C4D36F54ED Q24306316-E581D097-A4E4-414F-8CBE-8C8786819F74 Q24307469-74A31577-7770-41E2-AFF9-37CA161F6896 Q24307750-603F8EC5-D2B3-4C76-9D02-D45323ED2978 Q24311550-73F64CDF-8E2F-472E-B8F7-AAA5464DBA3D Q24311663-DEF60C05-4C22-4B97-A324-7DC6E32784FB Q24324032-A8274E5A-A76F-49C8-A498-E5EE31AFC865 Q24324035-1279EF4E-12D4-4CBD-AE99-0A9AE2D8E29E Q24324150-A8DC0A56-9662-4CC6-A7A8-9086C729FAC4 Q24328749-C6965EC6-3909-4E85-92C5-85189E5B3414 Q24336227-5D33AC64-5F08-4BBF-8305-70E7B806F1E4 Q24337103-4853FCBA-EBFD-4E83-9104-B58CD07E3A7B Q24339391-7788C492-2A94-46E6-961B-4513F4E0B2A3 Q24670460-83E715A6-C1FB-47BF-9DC8-6ED07BDC9945 Q24671304-6B79D208-AE4F-4690-B533-A782F66C401B Q24683232-5267D3B0-117C-4847-AD42-5257BCD2450D Q24793292-3A4A2AE5-E5B9-4F22-A3BE-69B7CEEDCC40 Q24800095-7C0694AB-BA45-413F-8DAF-48EA7FF29AA3 Q26739120-645AE00E-FF54-4AA5-AEAE-44FD9AEDB5A0 Q26798369-F7532AAA-EED7-4B17-A415-77E34749DF8D Q28073903-ADA61920-9960-43FB-A4E0-CDC258CE30EA Q28079350-339BE56F-93CB-43F5-AA1F-8BE5347044C1 Q28085076-5ACCCEE4-2712-4D32-B9A1-341EDAD2B1EB Q28087539-1F451462-4D95-4D50-B33B-C5D96F92B6E5 Q28235209-549355DA-3849-4D5D-AD20-3A5C9757EF61 Q28240447-86D73FC4-04EA-4681-9BD5-D8C243F8D877 Q28257534-403581EC-283F-4CFA-A686-8AA071058B35 Q28261166-5C43257F-1B96-41DD-AB76-AA0E086C0EB6 Q28299149-9741828A-C065-413E-948A-2443CF517D38 Q28393378-D21039C6-0D23-4DE9-859E-D53F0356BE41 Q28472324-FA469BD8-E2AE-47AF-9547-7C6C96E789A5 Q28505369-AA7D67FA-EC73-40E1-B362-B2C7B0B3ACAA Q28506706-239D5607-2E31-44A9-8687-9F2B58D0AEAA Q28513065-50EB7A38-676C-4BBB-9C8F-3AC07A698980 Q28540932-EE40D715-06F7-490B-9CC3-A65C99EA733B

P2860

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

http://www.wikidata.org/entity/Q24537700

description

2002 nî lūn-bûn

@nan

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@ast

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@en

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@nl

type

label

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@ast

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@en

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@nl

prefLabel

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@ast

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@en

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@nl

P1433

Q24537700-513A2844-6911-4239-BD26-9D43422DBCC9

P1476

Q24537700-8F748ABB-FBB0-4572-918E-A50C0C8E275C

P2093

Q24537700-106785B5-37E3-45C1-988C-7201ED8F18DF

Q24537700-3E767E0C-FD39-42CF-B3DB-D9DB8598E96D

Q24537700-719B2AED-A6A3-4213-B293-955FF667627A

Q24537700-727969C6-7966-4195-A034-E522CCBCD3C5

Q24537700-7CDDA38F-E9E4-4C3F-8BA3-EE0C6E4B8127

Q24537700-907A6857-F00A-4BA0-8598-DEF92BAECEE7

P2860

Q24537700-01211171-C8EF-43F8-B7A4-0CBA82F6F0CC

Q24537700-027D9E57-03D7-4521-B0C2-012FB2AF28FD

Q24537700-033C626B-C4EC-4F81-83F5-9795AA5C5D10

Q24537700-0EB3C0E4-9548-49DB-BE20-53800D9A8F06

Q24537700-1369A4D0-6F13-4FE8-BCB3-197E50529FAC

Q24537700-1C30B79D-B4C1-4FD7-8C3E-6C90B695469F

Q24537700-28BE96C4-8F4B-4DEF-8379-60BA71D9ABF4

Q24537700-36567049-6230-4C40-A280-751B831517B9

Q24537700-397E4273-3A42-46C9-9433-D810032A3E55

Q24537700-3E41FAB1-E366-44E1-A049-3DA2E49C207E

P304

Q24537700-5000E350-8C09-4C13-9C4B-937D04BD4B54

P31

Q24537700-C2A4F401-DAEE-466A-92BC-ABD1C147BAD5

P3181

Q24537700-830F46A8-AED4-47D3-BBB5-CE0645EB74B3

P356

Q24537700-1348F096-9D2F-437B-A000-716D699B8F76

P407

Q24537700-7B4126C6-6435-4132-A6AF-0327BFFD7728

P433

Q24537700-D30DA715-B1D0-472E-9CE7-84867685CF61

P478

Q24537700-3735B023-D34F-4D5E-AF54-6D1B360E2B5B

P50

Q24537700-88BBC6F0-6357-4DF5-BD2D-3B29A7C572EA

P577

Q24537700-3C9DC668-AD0D-4CEF-84C1-52566E2FEF3C

P5875

Q24537700-C0394F98-DEE8-4747-83A7-8D3CE8CBCC08

P698

Q24537700-C2FEE375-ACA5-4F8B-8141-280C7C24EBD6

P932

Q24537700-6EC6C80A-25DB-403F-938A-683F3E5FFAA2

P3181

P356

P1433

The EMBO Journal

P1476

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

@en

P2093

Akihiro Ito

http://www.w3.org/2001/XMLSchema#string

Chun-Hsiang Lai

http://www.w3.org/2001/XMLSchema#string

Jeffrey J Kovacs

http://www.w3.org/2001/XMLSchema#string

Tso-Pang Yao

http://www.w3.org/2001/XMLSchema#string

Yoshiharu Kawaguchi

http://www.w3.org/2001/XMLSchema#string

Yuichiro Higashimoto

http://www.w3.org/2001/XMLSchema#string

P2860

Three proteins define a class of human histone deacetylases related to yeast Hda1p

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

Functions of the MDM2 oncoprotein

P304

6236-45

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4215512

http://www.w3.org/2001/XMLSchema#string

P356

10.1093/EMBOJ/CDF616

http://www.w3.org/2001/XMLSchema#string

P407

P433

22

http://www.w3.org/2001/XMLSchema#string

P478

21

http://www.w3.org/2001/XMLSchema#string

P50

P577

2002-11-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

238311486

http://www.w3.org/2001/XMLSchema#string

P698

12426395

http://www.w3.org/2001/XMLSchema#string

P932

137207

http://www.w3.org/2001/XMLSchema#string