ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
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Explaining oscillations and variability in the p53-Mdm2 systemThe p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX proteinThe human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding proteinTBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescenceTRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradationGlioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressorExpression of the Bcl-3 proto-oncogene suppresses p53 activationAntiviral action of the tumor suppressor ARFCARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathwayA novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stabilityTumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradationPTEN regulation by Akt-EGR1-ARF-PTEN axisRibosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferationThe tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complexA novel ARF-binding protein (LZAP) alters ARF regulation of HDM2Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stabilityLZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)The Mdm2 oncoprotein interacts with the cell fate regulator NumbMDM2-HDAC1-mediated deacetylation of p53 is required for its degradationGerm line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced responseMDM2 suppresses p73 function without promoting p73 degradationInhibition of HDM2 and activation of p53 by ribosomal protein L23Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activationp19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland developmentTwist is a potential oncogene that inhibits apoptosisp53-independent functions of the p19(ARF) tumor suppressorA TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback controlA DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/MRibosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathwayNutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescenceP19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradationRegulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanismA nucleolar mechanism controlling cell proliferation in stem cells and cancer cellsOsteosarcoma: Cells-of-Origin, Cancer Stem Cells, and Targeted TherapiesMicrobial Regulation of p53 Tumor Suppressor
P2860
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P248
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P2860
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@ast
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en-gb
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@nl
type
label
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@ast
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en-gb
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@nl
prefLabel
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@ast
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en-gb
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@nl
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P921
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P1476
ARF promotes MDM2 degradation ...... p53 tumor suppression pathways
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(00)81401-4
P407
P577
1998-03-20T00:00:00Z