Monastrol inhibition of the mitotic kinesin Eg5. - Wikidata - awgldk - TriplyDB

Monastrol inhibition of the mitotic kinesin Eg5.

Monastrol inhibition of the mitotic kinesin Eg5.

http://www.wikidata.org/entity/Q24540254

about

Kinesin-5: cross-bridging mechanism to targeted clinical therapy Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5 NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site Real-time structural transitions are coupled to chemical steps in ATP hydrolysis by Eg5 kinesin Pathway of ATP hydrolysis by monomeric kinesin Eg5 Microtubule cross-linking triggers the directional motility of kinesin-5 ATPase mechanism of Eg5 in the absence of microtubules: insight into microtubule activation and allosteric inhibition by monastrol Kinesin-5 is essential for growth-cone turning Force generation by kinesin and myosin cytoskeletal motor proteins ATPase Cycle of the Nonmotile Kinesin NOD Allows Microtubule End Tracking and Drives Chromosome Movement The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5 The Molecular Mechanism of Hsp100 Chaperone Inhibition by the Prion Curing Agent Guanidinium Chloride "Snapshots"of Ispinesib-induced Conformational Changes in the Mitotic Kinesin Eg5 Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol A structural model for monastrol inhibition of dimeric kinesin Eg5.Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Kif11 dependent cell cycle progression in radial glial cells is required for proper neurogenesis in the zebrafish neural tube.Physical determinants of bipolar mitotic spindle assembly and stability in fission yeast.Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly.Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa.Cryo-electron tomography of microtubule-kinesin motor complexes Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK Spindle pole mechanics studied in mitotic asters: dynamic distribution of spindle forces through compliant linkages.Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.Dimeric Eg5 maintains processivity through alternating-site catalysis with rate-limiting ATP hydrolysis Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours.Overview of major classes of plant-derived anticancer drugs Inhibition of the Motor Protein Eg5/Kinesin-5 in Amyloid β-Mediated Impairment of Hippocampal Long-Term Potentiation and Dendritic Spine Loss.Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: a transient and time-resolved fluorescence study.Motor proteins and molecular motors: how to operate machines at the nanoscale.A Biologically-Based Computational Approach to Drug Repurposing for Anthrax Infection.The centrosome as potential target for cancer therapy and prevention.Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening.

P2860

Q21710690-99CCD11E-485A-4924-AF53-26FF2B24CC04 Q24598362-56EB5392-FC8F-4B46-A84E-92BAF43547E6 Q24605348-F86155CC-3D7D-4C12-8D55-E127FC21D488 Q24623319-98950B07-CD69-440B-93B7-0E7E747A01CB Q24634098-264B8782-F171-4DF6-AC6F-1ED93E085B4C Q24644762-999A35BE-DF43-4E86-8C4B-7B55F2F49CED Q24647999-D2FF5A3B-FC9E-4307-970B-FADEC85224AC Q24650875-CD17715B-14C4-46B7-B6E6-92C57AA8B35D Q24651756-6C3B7ACB-8307-4FB7-BCFF-97F68E9DD7BD Q26827691-F800F95D-C451-49F2-AB87-3CC498FAED97 Q27653383-2830B0F0-3176-4C9A-8580-72D08BFCE474 Q27675020-B22DE3DB-098E-4386-91DE-502787CD9A30 Q27675957-68D74999-4DC0-421F-91E8-23097243249F Q27678058-9C052892-3558-4EB1-94F3-64CD8A8D4083 Q27681421-4034CC58-3F76-4EC6-95BB-F323657BBA7C Q28076992-D3DE8CC8-C7F5-427D-89DA-13318A2D6E38 Q30409397-0D7E0A42-F5D7-4085-A895-A5AFC5B3FEF1 Q30477178-18559A5A-2FE7-41F5-A93D-1FE2BBD26191 Q30477323-3459AC7A-8A42-40B5-A634-B0F3F477ECFB Q30497206-E702A572-9A0B-42BE-A4C9-C02977827D21 Q30572804-98EB60B4-D399-4A92-AC9B-AFCCF3446626 Q30835689-5870E884-B015-4903-9F7D-36C785E3FE29 Q30847789-B4EA02CE-90AC-47B6-8331-AAA4C18ADCAF Q33344381-34D7CE67-FC45-43E9-A292-F2E23DA06F13 Q33467577-00A921DB-5798-4C50-8242-4FDAFB40EC93 Q33520141-F4E1CD7E-DA43-4D24-A16D-95D2B1111161 Q33666502-2EC6FD34-0CC4-405B-9784-440795A1DF23 Q34325704-66C393C6-F279-4971-8023-67748154786E Q34772202-DE8FEC52-033B-4F07-B83E-CC7EC3D314E2 Q35209477-8FBC4BD0-2E07-4EAF-82CE-26B02039299B Q35785839-9A99047D-7EFD-4B82-9EB6-345633C3836D Q36243553-03763499-3901-46D4-9422-BD66554A03E0 Q36494207-ED0F485E-C9E6-4069-9EBD-7715A318504E Q36735506-14D37041-F912-41A7-B647-B29A920E3DA4 Q36852481-A5295B35-E373-4BA4-AF26-75474C4905EA Q37348996-1F78529F-788A-4FFB-B79E-D7018614D36B Q37382357-A98CA45A-B094-44DD-8283-18D94A854540 Q37727941-DCC97F50-10EB-4A1D-93D8-0C58365D4555 Q38051759-BAE70BCF-B8AA-4F68-ACA6-1D9EF0A79039 Q38795153-F6BDB638-6D6A-44DB-B96F-EFDDF90D7E43

P2860

Monastrol inhibition of the mitotic kinesin Eg5.

http://www.wikidata.org/entity/Q24540254

description

2005 nî lūn-bûn

@nan

2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Monastrol inhibition of the mitotic kinesin Eg5

@nl

Monastrol inhibition of the mitotic kinesin Eg5.

@ast

Monastrol inhibition of the mitotic kinesin Eg5.

@en

type

label

Monastrol inhibition of the mitotic kinesin Eg5

@nl

Monastrol inhibition of the mitotic kinesin Eg5.

@ast

Monastrol inhibition of the mitotic kinesin Eg5.

@en

prefLabel

Monastrol inhibition of the mitotic kinesin Eg5

@nl

Monastrol inhibition of the mitotic kinesin Eg5.

@ast

Monastrol inhibition of the mitotic kinesin Eg5.

@en

P1433

Q24540254-0D19731F-A7A9-4969-94B4-02111881B50B

P1476

Q24540254-A7325B1F-390F-4E99-99D5-0689C706AC9C

P2093

Q24540254-03EA5EF4-3F52-418A-AC7F-C12E34398095

Q24540254-30A47C6D-D407-492A-8A2A-A7D9765493E0

Q24540254-6F99D769-5ED1-49A1-83EB-9503A5268F57

Q24540254-C807060D-0085-43EF-A0F3-C1BBB373AC79

P2860

Q24540254-08915C6A-F026-4505-8247-722848C16959

Q24540254-14407559-6A94-4B6C-B0DF-374AC710A731

Q24540254-15E2F6BB-CF36-4028-85D7-F56F836B9CF4

Q24540254-179DB532-6514-47B0-A948-1EB093EACC30

Q24540254-1B761741-D67F-4A6A-BEAD-4B6389CF0DC5

Q24540254-3062C09B-43E9-46F6-826B-98EC0ABA4AEB

Q24540254-34A3C266-EAFB-4EA1-B287-93583A38B392

Q24540254-37234F67-E4D4-4795-994D-62A59B5AE784

Q24540254-3AE1E976-B56B-41A3-96F6-765FFD4F48EB

Q24540254-3B6DA04B-9307-4634-9BC9-2179E4114DC3

P304

Q24540254-5959A70D-66AF-47C5-82B1-00E0E97503DA

P31

Q24540254-DF3A3A81-1F08-4FEB-B865-80BFF6956367

P356

Q24540254-C1074779-0E2A-4045-8529-2A7124C02F00

P407

Q24540254-0400715C-D4B5-4B8B-AD37-B0B75C5B952A

P433

Q24540254-4BF74D4A-D774-481E-AE5C-9C8B3816C96D

P478

Q24540254-495D4DF4-8483-4442-A1D0-EA27CB99D0F6

P577

Q24540254-246219CA-78B7-497E-8B78-ABC292D75D44

P5875

Q24540254-53618FC1-987B-45BA-9EEB-20FBB2E9DBE5

P698

Q24540254-17BE7A6F-E64B-4763-A223-777167CC3CA3

P921

Q24540254-FCA8D37D-4AB8-4C3B-9214-A9F567833B30

P932

Q24540254-5166E1C8-DA94-4D91-B351-19A1A1D68E0E

P356

P1433

Journal of Biological Chemistry

P1476

Monastrol inhibition of the mitotic kinesin Eg5.

@en

P2093

Jared C Cochran

http://www.w3.org/2001/XMLSchema#string

Joseph E Gatial

http://www.w3.org/2001/XMLSchema#string

Susan P Gilbert

http://www.w3.org/2001/XMLSchema#string

Tarun M Kapoor

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

Mechanistic analysis of the mitotic kinesin Eg5.

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker

Switch-based mechanism of kinesin motors

Inhibition of a mitotic motor protein: where, how, and conformational consequences

Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors.

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

P304

12658-12667

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M413140200

http://www.w3.org/2001/XMLSchema#string

P407

P433

13

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P577

2005-01-23T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

8066993

http://www.w3.org/2001/XMLSchema#string

P698

15665380

http://www.w3.org/2001/XMLSchema#string

P921

P932

1356610

http://www.w3.org/2001/XMLSchema#string