Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells - Wikidata - awgldk - TriplyDB

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

http://www.wikidata.org/entity/Q24548951

about

Eukaryotic elongation factor 2 kinase as a drug target in cancer, and in cardiovascular and neurodegenerative diseases eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy The molecular mechanism of eukaryotic elongation factor 2 kinase activation mTOR and cancer therapy Hypoxia Regulates mTORC1-Mediated Keratinocyte Motility and Migration via the AMPK Pathway CPEB2-eEF2 interaction impedes HIF-1α RNA translation Suppression of replicative senescence by rapamycin in rodent embryonic cells Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells.Proteomic analysis of anoxia tolerance in the developing zebrafish embryo.Modulation of C. elegans touch sensitivity is integrated at multiple levels.Nonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.New frontiers in translational control of the cancer genome Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.Hypoxia suppresses conversion from proliferative arrest to cellular senescence.Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer The Pim protein kinases regulate energy metabolism and cell growth Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer.The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.Hypoxia integration in the serological proteome analysis unmasks tumor antigens and fosters the identification of anti-phospho-eEF2 antibodies as potential cancer biomarkers.The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.Hormesis does not make sense except in the light of TOR-driven aging.Temporal regulation of HIF-1 and NF-κB in hypoxic hepatocarcinoma cells.Identification of mRNAs that continue to associate with polysomes during hypoxia.Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis Hypoxia Induces Autophagy through Translational Up-Regulation of Lysosomal Proteins in Human Colon Cancer Cells Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells.DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha Hypoxia and gerosuppression: the mTOR saga continues Translational repression during chronic hypoxia is dependent on glucose levels.Systemic Reprogramming of Translation Efficiencies on Oxygen Stimulus Expression status and prognostic significance of mammalian target of rapamycin pathway members in urothelial carcinoma of urinary bladder after cystectomy.Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells Metastasis and stem cell pathways Hypoxia-induced signaling in the cardiovascular system.Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells.

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P2860

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells

http://www.wikidata.org/entity/Q24548951

description

2006 nî lūn-bûn

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2006 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2006 թվականի մայիսին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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type

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

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MCB.26.10.3955-3965.2006

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Molecular and Cellular Biology

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Hypoxia inhibits protein synth ...... coupled in breast cancer cells

@en

P2093

Silvia Formenti

http://www.w3.org/2001/XMLSchema#string

Steve Braunstein

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P2860

Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes

Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA

Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

Breast cancer cell lines: friend or foe?

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

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3955-3965

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scholarly article

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10

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26

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Robert J Schneider

Eileen Connolly

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2006-05-01T00:00:00Z

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7133818

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16648488

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1489005

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