Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
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Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recoveryEssential role for poly (ADP-ribosyl)ation in mouse preimplantation developmentInhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repairTrial watch - inhibiting PARP enzymes for anticancer therapyLow ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines.Understanding specific functions of PARP-2: new lessons for cancer therapyThe mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with AtmInteraction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.ATM signalling and cancer.Loss of ATM kinase activity leads to embryonic lethality in miceInputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stressParp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation.The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.Kinase-dead ATM protein causes genomic instability and early embryonic lethality in miceAtaxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination.Poly(ADP-ribose) polymerase-1 is a survival factor for radiation-exposed intestinal epithelial stem cells in vivo.Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.PARP and PARG inhibitors--new therapeutic targets in cancer treatment.The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets.PARP-1 and PARP-2: New players in tumour development.Predictive biomarkers for cancer therapy with PARP inhibitors.Ataxia telangiectasia mutated (ATM) signaling network is modulated by a novel poly(ADP-ribose)-dependent pathway in the early response to DNA-damaging agents.PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cells.The role of poly ADP-ribosylation in the first wave of DNA damage response.Developmental regulation and in vitro culture effects on expression of DNA repair and cell cycle checkpoint control genes in rhesus monkey oocytes and embryos.
P2860
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P2860
Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
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2001 nî lūn-bûn
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2001 թուականի Մարտին հրատարակուած գիտական յօդուած
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2001 թվականի մարտին հրատարակված գիտական հոդված
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2001年の論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年論文
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2001年论文
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name
Early embryonic lethality in P ...... oliferation during development
@ast
Early embryonic lethality in P ...... oliferation during development
@en
Early embryonic lethality in P ...... oliferation during development
@nl
type
label
Early embryonic lethality in P ...... oliferation during development
@ast
Early embryonic lethality in P ...... oliferation during development
@en
Early embryonic lethality in P ...... oliferation during development
@nl
prefLabel
Early embryonic lethality in P ...... oliferation during development
@ast
Early embryonic lethality in P ...... oliferation during development
@en
Early embryonic lethality in P ...... oliferation during development
@nl
P2093
P2860
P1476
Early embryonic lethality in P ...... oliferation during development
@en
P2093
A Wynshaw-Boris
G de Murcia
J Ménisser-de Murcia
O Wendling
P2860
P304
P356
10.1128/MCB.21.5.1828-1832.2001
P407
P577
2001-03-01T00:00:00Z