Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
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Poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancerDNA-repair pathway inhibitors for the treatment of ovarian cancerMicroRNA-138 modulates DNA damage response by repressing histone H2AX expressionSusceptibility pathways in Fanconi's anemia and breast cancerNucleases in homologous recombination as targets for cancer therapyPARPs and the DNA damage responseATM Kinase Is Required for Telomere Elongation in Mouse and Human CellsThe ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cellsInteraction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a pediatric brain tumor consortium reportHIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage responseDifferential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.Strategies for the Use of Poly(adenosine diphosphate ribose) Polymerase (PARP) Inhibitors in Cancer Therapy.Poly (ADP-ribose) polymerase inhibitor, an effective radiosensitizer in lung and pancreatic cancers.New molecular targets in radiotherapy: DNA damage signalling and repair in targeted and non-targeted cellsSensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.The Dual Roles of MYC in Genomic Instability and Cancer ChemoresistanceCetuximab augments cytotoxicity with poly (adp-ribose) polymerase inhibition in head and neck cancerSmall fragment homologous replacement: evaluation of factors influencing modification efficiency in an eukaryotic assay system.The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies.Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates.ATM signalling and cancer.Loss of ATM kinase activity leads to embryonic lethality in miceDevelopment of synthetic lethality anticancer therapeutics.DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer.BRCA1, PARP, and 53BP1: conditional synthetic lethality and synthetic viability.Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations.RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.Beta-amyloid increases the expression level of ATBF1 responsible for death in cultured cortical neurons.The ups and downs of DNA repair biomarkers for PARP inhibitor therapiesThe PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.Rare variants in the ATM gene and risk of breast cancer53BP1 depletion causes PARP inhibitor resistance in ATM-deficient breast cancer cells.Metabolic responses induced by DNA damage and poly (ADP-ribose) polymerase (PARP) inhibition in MCF-7 cells.Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase.Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates.ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity.Poly(Adenosine diphosphate-ribose) polymerase inhibitors in cancer treatmentTherapeutic potential of drugs to modulate DNA repair in cancer.
P2860
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P2860
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
description
2006 nî lūn-bûn
@nan
2006 թուականին հրատարակուած գիտական յօդուած
@hyw
2006 թվականին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@ast
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@en
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@nl
type
label
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@ast
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@en
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@nl
prefLabel
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@ast
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@en
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@nl
P2860
P3181
P356
P1476
Inhibition of poly (ADP-ribose ...... omologous recombination repair
@en
P2093
Helen E Bryant
P2860
P304
P3181
P356
10.1093/NAR/GKL108
P407
P577
2006-01-01T00:00:00Z