Siah-1 binds and regulates the function of Numb - Wikidata - awgldk - TriplyDB

Siah-1 binds and regulates the function of Numb

Siah-1 binds and regulates the function of Numb

http://www.wikidata.org/entity/Q24555052

about

Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1 Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis Reciprocal repression between P53 and TCTP Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller cells Aberrant regulation of FBW7 in cancer.Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.The ubiquitin ligase Siah2 and the hypoxia response.miR-135A regulates preimplantation embryo development through down-regulation of E3 Ubiquitin Ligase Seven In Absentia Homolog 1A (SIAH1A) expression.Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.Normal p53 function in primary cells deficient for Siah genes.Regulation of 2-oxoglutarate (alpha-ketoglutarate) dehydrogenase stability by the RING finger ubiquitin ligase Siah.Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptors A binding motif for Siah ubiquitin ligase.Generation and analysis of Siah2 mutant mice.Infant sex-specific placental cadmium and DNA methylation associations.UV-Induced Wnt7a in the Human Skin Microenvironment Specifies the Fate of Neural Crest-Like Cells via Suppression of Notch.Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress.Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis Asymmetric localization of numb in the chick somite and the influence of myogenic signals ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling.Network Modeling Identifies Patient-specific Pathways in Glioblastoma.Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer.Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy.Numb and Alzheimer's disease: the current picture E2F1 represses beta-catenin/TCF activity by direct up-regulation of Siah1.SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation.Seven in Absentia E3 Ubiquitin Ligases: Central Regulators of Neural Cell Fate and Neuronal Polarity.Seven in absentia proteins affect plant growth and nodulation in Medicago truncatula.Sox9 regulates self-renewal and tumorigenicity by promoting symmetrical cell division of cancer stem cells in hepatocellular carcinoma.Inducing stable reversion to achieve cancer control.Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology

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Siah-1 binds and regulates the function of Numb

http://www.wikidata.org/entity/Q24555052

description

2001 nî lūn-bûn

@nan

2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2001年の論文

@ja

2001年論文

@yue

2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

@zh-mo

2001年論文

@zh-tw

2001年论文

@wuu

name

Siah-1 binds and regulates the function of Numb

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Siah-1 binds and regulates the function of Numb

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Siah-1 binds and regulates the function of Numb

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type

label

Siah-1 binds and regulates the function of Numb

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Siah-1 binds and regulates the function of Numb

@en

Siah-1 binds and regulates the function of Numb

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prefLabel

Siah-1 binds and regulates the function of Numb

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Siah-1 binds and regulates the function of Numb

@en

Siah-1 binds and regulates the function of Numb

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Siah-1 binds and regulates the function of Numb

@en

P2093

A Israël

http://www.w3.org/2001/XMLSchema#string

A Telerman

http://www.w3.org/2001/XMLSchema#string

B J Passer

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M C Gendron

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M Oren

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M Tuynder

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N Amzallag-Elbaz

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N Privat

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R Amson

http://www.w3.org/2001/XMLSchema#string

S Prieur

http://www.w3.org/2001/XMLSchema#string

P2860

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins

SMART, a simple modular architecture research tool: identification of signaling domains

Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression

P304

15067-15072

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scholarly article

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410724

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10.1073/PNAS.261571998

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26

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98

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Tamar Juven-Gershon

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2001-12-01T00:00:00Z

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235613377

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