Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.
about
AIP4/Itch regulates Notch receptor degradation in the absence of ligandNumb activates the E3 ligase Itch to control Gli1 function through a novel degradation signalThe adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathwayIdentification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with NumbPCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanismaPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein XNotch and EGFR pathway interaction regulates neural stem cell number and self-renewalSignaling mechanisms regulating adult neural stem cells and neurogenesisNotch signaling in CD4 and CD8 T cell developmentIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1The cilia-regulated proteasome and its role in the development of ciliopathies and cancerNeuroplasticity and Repair in Rodent Neurotoxic Models of Spinal Motoneuron DiseaseNon-canonical Notch signaling: emerging role and mechanismThe Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organsChromatin signaling in muscle stem cells: interpreting the regenerative microenvironmentRegulation of the nuclear localization of the human Nedd4-related WWP1 protein by NotchLnx2 ubiquitin ligase is essential for exocrine cell differentiation in the early zebrafish pancreasNeuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1Mind bomb-2 is an E3 ligase for Notch ligandTargeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborizationSnail induction is an early response to Gli1 that determines the efficiency of epithelial transformationAdapting for endocytosis: roles for endocytic sorting adaptors in directing neural development.Manic fringe inhibits tumor growth by suppressing Notch3 degradation in lung cancerHarnessing the power of the endosome to regulate neural development.A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.Numb family proteins are essential for cardiac morphogenesis and progenitor differentiationNumb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear.NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells.Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancerIdentification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization.Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes.Notch is a critical regulator in cervical cancer by regulating Numb splicing.Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesisImmunoprofiling of Adult-Derived Human Liver Stem/Progenitor Cells: Impact of Hepatogenic Differentiation and InflammationStress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.Aberrant regulation of FBW7 in cancer.Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells.
P2860
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P2860
Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@ast
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@en
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@nl
type
label
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@ast
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@en
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@nl
prefLabel
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@ast
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@en
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@nl
P2860
P356
P1476
Mammalian numb proteins promot ...... e Notch1 intracellular domain.
@en
P2093
C Jane McGlade
Melanie A McGill
P2860
P304
23196-23203
P356
10.1074/JBC.M302827200
P407
P577
2003-04-07T00:00:00Z