WWOX: a candidate tumor suppressor gene involved in multiple tumor types - Wikidata - awgldk - TriplyDB

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

http://www.wikidata.org/entity/Q24555184

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Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein IGRhCellID: integrated genomic resources of human cell lines for identification Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers Functional association between Wwox tumor suppressor protein and p73, a p53 homolog Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma Targeted deletion of Wwox reveals a tumor suppressor function WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis WWOX, the common chromosomal fragile site, FRA16D, cancer gene Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease Tumor suppressor and hepatocellular carcinoma The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer.Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene Image-based assessment of growth and signaling changes in cancer cells mediated by direct cell-cell contact.Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk.WWOX gene is associated with HDL cholesterol and triglyceride levels.Impact of WWOX alterations on p73, ΔNp73, p53, cell proliferation and DNA ploidy in salivary gland neoplasms.Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas.WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.WWOX protein expression in normal human tissues.Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status WWOX gene restoration prevents lung cancer growth in vitro and in vivo Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours.WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.DNA instability at chromosomal fragile sites in cancer WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear.Oncosuppressor proteins of fragile sites are reduced in cervical cancer.Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiforme WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.Chromosomal aberrations related to metastasis of human solid tumors WWOX expression in colorectal cancer--a real-time quantitative RT-PCR study.Epigenetic and genetic alterations affect the WWOX gene in head and neck squamous cell carcinoma.Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types

http://www.wikidata.org/entity/Q24555184

description

2001 nî lūn-bûn

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2001 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types

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type

label

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types

@en

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

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prefLabel

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

@ast

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

@en

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

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Proceedings of the National Academy of Sciences of the United States of America

P1476

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

@en

P2093

A J Paige

http://www.w3.org/2001/XMLSchema#string

C Taylor

http://www.w3.org/2001/XMLSchema#string

D J Porteous

http://www.w3.org/2001/XMLSchema#string

D Scott

http://www.w3.org/2001/XMLSchema#string

H Gabra

http://www.w3.org/2001/XMLSchema#string

J E Watson

http://www.w3.org/2001/XMLSchema#string

J F Smyth

http://www.w3.org/2001/XMLSchema#string

K J Taylor

http://www.w3.org/2001/XMLSchema#string

S Farrington

http://www.w3.org/2001/XMLSchema#string

S G Hillier

http://www.w3.org/2001/XMLSchema#string

P2860

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes

Muir-Torre-like syndrome in Fhit-deficient mice

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.

Chromosomal fragile site FRA16D and DNA instability in cancer.

Deletion mapping of chromosome 16q in hepatocellular carcinoma.

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11417-22

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scholarly article

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10.1073/PNAS.191175898

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20

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98

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11572989

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58744

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