Cancer-specific chromosome alterations in the constitutive fragile region FRA3B. - Wikidata - awgldk - TriplyDB

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

http://www.wikidata.org/entity/Q36396981

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WWOX: a candidate tumor suppressor gene involved in multiple tumor types Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit Molecular basis for expression of common and rare fragile sites Common fragile sites: genomic hotspots of DNA damage and carcinogenesis The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1 BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function Breakpoint analysis of the pericentric inversion distinguishing human chromosome 4 from the homologous chromosome in the chimpanzee (Pan troglodytes).A novel approach to simultaneously scan genes at fragile sites DNA structure and the Werner protein modulate human DNA polymerase delta-dependent replication dynamics within the common fragile site FRA16D.Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation.Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.The clinical significance of fragile sites on human chromosomes.Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic Common fragile site tumor suppressor genes and corresponding mouse models of cancer.Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27 Two breakpoint clusters at fragile site FRA3B form phased nucleosomes.Global mapping of DNA conformational flexibility on Saccharomyces cerevisiae.Loss of FHIT expression in transitional cell carcinoma of the urinary bladder.Causes and consequences of DNA hypomethylation in human cancer.miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.Replication stress induces tumor-like microdeletions in FHIT/FRA3B Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.Role of DNA secondary structures in fragile site breakage along human chromosome 10 Haploinsufficiency of DNA Damage Response Genes and their Potential Influence in Human Genomic Disorders.Replication fork recovery and regulation of common fragile sites stability.Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes.Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors.Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer.Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats.Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements.Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study.L1 retrotransposons in human cancers Non-random features of loop-size chromatin fragmentation.FRA3B and other common fragile sites: the weakest links.Investigation of genetic susceptibility to non-small cell lung cancer by fragile site expression.Molecular processes of chromosome 9p21 deletions in human cancers.Loss of FHIT protein expression is a marker of adverse evolution in good prognosis localized breast cancer.The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted FHIT alleles.

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P2860

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

http://www.wikidata.org/entity/Q36396981

description

1999 nî lūn-bûn

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年學術文章

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1999年學術文章

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1999年學術文章

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name

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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type

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Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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Proceedings of the National Academy of Sciences of the United States of America

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Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

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H Alder

http://www.w3.org/2001/XMLSchema#string

H Inoue

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K Huebner

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K Mimori

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L Berk

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P2860

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

Genetic applications of an inverse polymerase chain reaction

Basic local alignment search tool

Prediction of complete gene structures in human genomic DNA

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

FHITness and cancer.

LINE-1 elements at the sites of molecular rearrangements in Alport syndrome-diffuse leiomyomatosis

Fragile sites-cytogenetic similarity with molecular diversity.

Chromosome breakage and recombination at fragile sites

Predicting internal exons by oligonucleotide composition and discriminant analysis of spliceable open reading frames.

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Carlo Maria Croce

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